Evidence map›Paper›PMID 27385383›Full record

ArticleThe international journal of neuropsychopharmacology2016

Parvalbumin Interneurons of Central Amygdala Regulate the Negative Affective States and the Expression of Corticotrophin-Releasing Hormone During Morphine Withdrawal.

Li Wang, Minjie Shen, Changyou Jiang, Lan Ma, Feifei Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. A widespread internal brain state for fentanyl withdrawal.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Parabrachial CGRP Neurons Regulate Opioid Reinforcement.bioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Li WangState Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China (Drs L Wang, Ma, F Wang, and Shen, and Mr Jiang); Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China (Dr L Wang).
Minjie ShenState Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China (Drs L Wang, Ma, F Wang, and Shen, and Mr Jiang); Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China (Dr L Wang).
Changyou JiangState Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China (Drs L Wang, Ma, F Wang, and Shen, and Mr Jiang); Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China (Dr L Wang).
Lan MaState Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China (Drs L Wang, Ma, F Wang, and Shen, and Mr Jiang); Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China (Dr L Wang) lanma@shmu.edu.cn ffwang@fudan.edu.cn.
Feifei WangState Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China (Drs L Wang, Ma, F Wang, and Shen, and Mr Jiang); Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China (Dr L Wang) lanma@shmu.edu.cn ffwang@fudan.edu.cn.
Fudan University · CNState Key Laboratory of Medical NeurobiologyShanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe central nucleus of the amygdala (CeA) is a crucial component of the neuronal circuitry mediating aversive emotion. Its role in the negative affective states during drug withdrawal includes changes in opioidergic, GABAergic, and corticotropin-releasing factor neurotransmission. However, the modulation of the neurobiological interconnectivity in the CeA and its effects in the negative reinforcement of drug dependents are poorly understood.

methodWe performed electrophysiological recordings to assess the membrane excitability of parvalbumin (PV)

resultChronic morphine withdrawal increased the firing rate of CeA PV

conclusionThe activity of PV

Indexed as

AffectBehavior, AnimalMorphineAnimalsAnxietyCentral Amygdaloid NucleusCorticotropin-Releasing HormoneDisease Models, AnimalExcitatory Postsynaptic PotentialsFeeding BehaviorGenotypeInterneuronsMaze LearningMice, Inbred C57BLMice, TransgenicMiniature Postsynaptic PotentialsCorticotropin-Releasing HormoneMorphineParvalbuminsRNA, MessengerSaccharincentral amygdalaCRHmorphine withdrawalnegative affective statesPV

Identifiers

PMID27385383
PMCPMC5137277
OpenAlexW2468781160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.