ArticleAdvanced healthcare materials2016
Syndesome Therapeutics for Enhancing Diabetic Wound Healing.
Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Role of Extracellular Vesicles in Skin Barrier Repair: Applications in Atopic Dermatitis and Chronic Wounds.International journal of nanomedicine · 2026Review
- The Importance of Sex-Based Comparisons in Preclinical Nanomedicine and Regenerative Chronic Wound Therapies.ACS biomaterials science & engineering · 2025Review
- Strategies to enhance the efficacy of FGF2-based therapies for skin wound healing.Archives of dermatological research · 2024Review
- Biomimetic strategies for the deputization of proteoglycan functions.Frontiers in cell and developmental biology · 2024Review
- Chitosan-Based Dressing as a Sustained Delivery System for Bioactive Cytokines.International journal of molecular sciences · 2023Article
- [Research advances on biomaterials for the delivery of growth factors to regulate wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Transmembrane stem cell factor protein therapeutics enhance revascularization in ischemia without mast cell activation.Nature communications · 2022Article
- Cell-Inspired Biomaterials for Modulating Inflammation.Tissue engineering. Part B, Reviews · 2022Review
- Immunomodulatory biomaterial-based wound dressings advance the healing of chronic wounds via regulating macrophage behavior.Regenerative biomaterials · 2022Review
- The Anti-inflammatory and Proangiogenic Properties of High-Density Lipoproteins: An Emerging Role in Diabetic Wound Healing.Advances in wound care · 2021Review
- BET bromodomain inhibitors regulate keratinocyte plasticity.Nature chemical biology · 2021Article
- Biomimetic Hydrogels to Promote Wound Healing.Frontiers in bioengineering and biotechnology · 2021Review
- Fibroblast Growth Factor in Diabetic Foot Ulcer: Progress and Therapeutic Prospects.Frontiers in endocrinology · 2021Review
- Therapeutic strategies for enhancing angiogenesis in wound healing.Advanced drug delivery reviews · 2019Review
- Modulation of inflammation in wounds of diabetic patients treated with porcine urinary bladder matrix.Regenerative medicine · 2019Article
- Predictive Approach Identifies Molecular Targets and Interventions to Restore Angiogenesis in Wounds With Delayed Healing.Frontiers in physiology · 2019Article
- Proteoglycans in Biomedicine: Resurgence of an Underexploited Class of ECM Molecules.Frontiers in pharmacology · 2019Review
- Highly Diluted Acetylcholine Promotes Wound Repair in anAdvances in wound care · 2018Article
- Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair.Advanced drug delivery reviews · 2018Review
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Chronic wounds represent a major healthcare and economic problem worldwide. Advanced wound dressings that incorporate bioactive compounds have great potential for improving outcomes in patients with chronic wounds but significant challenges in designing treatments that are effective in long-standing, nonhealing wounds. Here, an optimized wound healing gel was developed that delivers syndecan-4 proteoliposomes ("syndesomes") with fibroblast growth factor-2 (FGF-2) to enhance diabetic wound healing. In vitro studies demonstrate that syndesomes markedly increase migration of keratinocytes and fibroblasts isolated from both nondiabetic and diabetic donors. In addition, syndesome treatment leads to increased endocytic processing of FGF-2 that includes enhanced recycling of FGF-2 to the cell surface after uptake. The optimized syndesome formulation was incorporated into an alginate wound dressing and tested in a splinted wound model in diabetic, ob/ob mice. It was found that wounds treated with syndesomes and FGF-2 have markedly enhanced wound closure in comparison to wounds treated with only FGF-2. Moreover, syndesomes have an immunomodulatory effect on wound macrophages, leading to a shift toward the M2 macrophage phenotype and alterations in the wound cytokine profile. Together, these studies show that delivery of exogenous syndecan-4 is an effective method for enhancing wound healing in the long-term diabetic diseased state.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.