ArticleScientific reports2016
A high-sensitivity HPLC assay for measuring intracellular Na(+) and K(+) and its application to Plasmodium falciparum infected erythrocytes.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Development of Optical Nanosensors for Detection of Potassium Ions and Assessment of Their Biocompatibility with Corneal Epithelial Cells.ACS omega · 2024Article
- Changes in KInternational journal of molecular sciences · 2023Review
- Article
- Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.Antimicrobial agents and chemotherapy · 2021Article
- Characterization of the ATP4 ion pump inThe Journal of biological chemistry · 2019Article
- Biochemical characterization and chemical inhibition of PfATP4-associated NaThe Journal of biological chemistry · 2018Article
- Diverse antimalarials from whole-cell phenotypic screens disrupt malaria parasite ion and volume homeostasis.Scientific reports · 2018Article
- Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials.Antimicrobial agents and chemotherapy · 2018Article
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Authors and funding
2 authors.
Funding
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Abstract
The measurement of intracellular ion concentrations, and the screening of chemical agents to identify molecules targeting ion transport, has traditionally involved low-throughput techniques. Here we present a novel HPLC method that allows the rapid, high-sensitivity measurement of cell Na(+) and K(+) content, demonstrating its utility by monitoring the ionic changes induced in the intracellular malaria parasite by the new spiroindolone antimalarial KAE609.
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