Evidence map›Paper›PMID 27385067›Full record

ArticleEnvironmental health perspectives2017

Biomonitoring in the Era of the Exposome.

Kristine K Dennis, Elizabeth Marder, David M Balshaw, Yuxia Cui, Michael A Lynes, Gary J Patti, Stephen M Rappaport, Daniel T Shaughnessy, Martine Vrijheid, Dana Boyd Barr

Registry-linked trialAbstract read
In one paragraph

Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05780047 (Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals), which is not on this map. Cited by 93 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05780047 nacompletednot on this mapstarted 2022, after this paper: background citation

Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals (EDCs) in Women of Child-Bearing Age and Their Partners

TypeinterventionalSponsorMillion Marker Wellness, Inc.Ran2022 to 2022Enrolled434ConditionsEndocrine Disrupting Chemicals, Environmental Exposure, Health Literacy, Bisphenol AArmsMail-in Urine Test for EDCs
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2019
    Trial
  4. Review
  5. Article
  6. Article
  7. Will Chemical Exposomics Be Ready for a Human Exposome Project?Environmental science & technology · 2026
    Article
  8. iScience · 2026
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Global research trends on the human exposome: a bibliometric analysis (2005-2024).Environmental science and pollution research international · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Kristine K DennisDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Elizabeth Marder
David M Balshaw
Yuxia Cui
Michael A Lynes
Gary J Patti
Stephen M Rappaport
Daniel T Shaughnessy
Martine Vrijheid
Dana Boyd Barr

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2013 to 2026
$22.6M
Graduate and Postdoctoral Training in ToxicologyT32ES012870 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2004 to 2026
$9.1M
NIEHS NIH HHS P30 ES019776NIEHS NIH HHS T32 ES012870
6 · The paper itself

Abstract

backgroundThe term "exposome" was coined in 2005 to underscore the importance of the environment to human health and to bring research efforts in line with those on the human genome. The ability to characterize environmental exposures through biomonitoring is key to exposome research efforts.

objectivesOur objectives were to describe why traditional and nontraditional (exposomic) biomonitoring are both critical in studies aiming to capture the exposome and to make recommendations on how to transition exposure research toward exposomic approaches. We describe the biomonitoring needs of exposome research and approaches and recommendations that will help fill the gaps in the current science. DISCUSSION: Traditional and exposomic biomonitoring approaches have key advantages and disadvantages for assessing exposure. Exposomic approaches differ from traditional biomonitoring methods in that they can include all exposures of potential health significance, whether from endogenous or exogenous sources. Issues of sample availability and quality, identification of unknown analytes, capture of nonpersistent chemicals, integration of methods, and statistical assessment of increasingly complex data sets remain challenges that must continue to be addressed.

conclusionsTo understand the complexity of exposures faced throughout the lifespan, both traditional and nontraditional biomonitoring methods should be used. Through hybrid approaches and the integration of emerging techniques, biomonitoring strategies can be maximized in research to define the exposome.

Indexed as

Genome, HumanEnvironmental ExposureEnvironmental HealthEnvironmental MonitoringHumans

Identifiers

PMID27385067
PMCPMC5381997

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.