Evidence map›Paper›PMID 27385004›Full record

ArticleOncotarget2016

mTOR: Alzheimer's disease prevention for APOE4 carriers.

Ai-Ling Lin, D Allan Butterfield, Arlan Richardson

Abstract readEditorialComment
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. mTOR inhibition enhances synaptic and mitochondrial function in Alzheimer's disease in an APOE genotype-dependent manner.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Ai-Ling LinSanders-Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
D Allan ButterfieldSanders-Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
Arlan RichardsonSanders-Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.

Funding

Multi-Modal MRI to Assess Alzheimer's Disease Prevention in an APOE4 MouseModelR01AG054459 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIN, AI-LING · 2017 to 2021
$3.0M
Neuroimaging Assessments of Brain Integrity in Aging MiceK01AG040164 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LIN, AI-LING · 2012 to 2016
$462k
NIA NIH HHS K01 AG040164NIA NIH HHS R01 AG054459
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseApolipoprotein E4AnimalsMiceMice, TransgenicSirolimusTOR Serine-Threonine KinasesApolipoprotein E4SirolimusTOR Serine-Threonine KinasesAlzheimer diseasemTORrapamycin

Identifiers

PMID27385004
PMCPMC5216689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.