Evidence map›Paper›PMID 27384991›Full record

SynthesisOncotarget2016

Associations between CYP1A1 rs1048943 A > G and rs4646903 T > C genetic variations and colorectal cancer risk: Proof from 26 case-control studies.

Xueru Zhu, Zhao Wang, Jing He, Weiye Wang, Wenji Xue, Yiwei Wang, Leizhen Zheng, Mei-Ling Zhu

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  9. Anti-Colorectal Cancer Mechanisms of Formononetin Identified by Network Pharmacological Approach.Medical science monitor : international medical journal of experimental and clinical research · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xueru ZhuDepartment of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yangpu, Shanghai, China.
Zhao WangSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.
Jing HeSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.
Weiye WangShanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yangpu, Shanghai, China.
Wenji XueDepartment of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yangpu, Shanghai, China.
Yiwei WangDepartment of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yangpu, Shanghai, China.
Leizhen ZhengDepartment of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yangpu, Shanghai, China.
Mei-Ling ZhuDepartment of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yangpu, Shanghai, China.
XinHua Hospital · CNGuangzhou Medical University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytochrome P450 1A1 (CYP1A1) enzyme is one of the most important metabolizing enzymes responsible for the metabolism of numerous xenobiotics. Numerous individual case-control studies have investigated the associations between the CYP1A1 rs1048943 A > G and rs4646903 T > C genetic variations and colorectal cancer (CRC) risk, but the conclusions were controversial. To obtain a scientific conclusion, we performed a meta-analysis based on a total of 26 publications, including 20 studies with 8665 cases and 9953 controls on rs1048943 A > G and 19 studies with 6416 cases and 7551 controls on rs4646903 T > C, respectively. The pooled analysis indicated that rs1048943 A > G was associated with an increased risk of CRC (G vs. A: OR = 1.28, 95% CI = 1.08-1.52; GG vs. AA: OR = 1.54, 95% CI = 1.25-1.91; GA vs. AA: OR = 1.26, 95% CI = 1.00-1.60; GG/GA vs. AA: OR = 1.31, 95% CI = 1.05-1.64; GG vs. GA/AA. OR = 1.56, 95% CI = 1.26-1.91). Stratification analysis showed the association between rs1048943 A > G and CRC risk was more obvious in studies with the population-based (PB) design or high quality score. The association between rs4646903 T > C and CRC risk did not reach statistical significance in the pooled analysis as well as stratification analysis. This meta-analysis demonstrated CYP1A1 rs1048943 A > G may increase the susceptibility to CRC instead of rs4646903 T > C. This conclusion suggested CYP1A1 may contribute to the pathogenesis of CRC.

Indexed as

Polymorphism, Single NucleotideCase-Control StudiesColorectal NeoplasmsCytochrome P-450 CYP1A1Genetic Association StudiesGenetic Predisposition to DiseaseHumansRisk FactorsCYP1A1 protein, humanCytochrome P-450 CYP1A1colorectal cancerCYP1A1meta-analysispolymorphism

Identifiers

PMID27384991
PMCPMC5239481
OpenAlexW2464935366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.