ArticleOrthopaedic surgery2016
Delay in Diagnosis and Its Effect on Clinical Outcome in High-grade Sarcoma of Bone: A Referral Oncological Centre Study.
Article in Orthopaedic surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cancer diagnostic tools to aid decision-making in primary care: mixed-methods systematic reviews and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2020Pooled it
- The sarcoma diagnostic interval: a systematic review on length, contributing factors and patient outcomes.ESMO open · 2020Pooled it
- Maxillary chondrosarcoma: a case report.Journal of medical case reports · 2026Article
- [Artificial intelligence in orthopaedic oncology].Orthopadie (Heidelberg, Germany) · 2026Review
- Actionable diagnostic delay in primary malignant bone tumors: a trigger-to-action framework for first-contact clinicians.Frontiers in oncology · 2026Review
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- Do Patients of Different Levels of Affluence Receive Different Care for Pediatric Osteosarcomas? One Institution's Experience.Clinical orthopaedics and related research · 2025Article
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- DIAGNOSTIC COMPETENCE IN BONE TUMORS: INFLUENCE OF ONCO-ORTHOPEDIC TRAINING.Acta ortopedica brasileira · 2025Article
- Clinical activity in general practice before sarcoma diagnosis: an Australian cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024Article
- An Uncommon Presentation of Osteosarcoma in a Child: A Case Report.Journal of orthopaedic case reports · 2024Article
- Assessment of Medical Students' Knowledge of Imaging Methods for Bone Sarcomas.Journal of cancer education : the official journal of the American Association for Cancer Education · 2023Article
- Deep Learning-Based Detection of Bone Tumors around the Knee in X-rays of Children.Journal of clinical medicine · 2023Article
- Epidemiology and survival factors for sarcoma patients in minority populations: a SEER-retrospective study.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Article
- Incidence and outcomes of delayed presentation and surgery in peritoneal surface malignancies.Frontiers in oncology · 2023Article
- Delay in Diagnosis and Treatment of Primary Bone Tumors during COVID-19 Pandemic in Poland.Cancers · 2022Article
- Article
- Delay in diagnosis of primary osteosarcoma of bone in children: Have we improved in the last 15 years and what is the impact of delay on diagnosis?Journal of bone oncology · 2021Article
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4 authors.
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Abstract
objectiveTo investigate delay in diagnosis by both patients and doctors, and to evaluate its effect on outcomes of high-grade sarcoma of bone in a single-referral oncological center.
methodsFifty-four patients with osteosarcoma, 29 with Ewing sarcoma and 19 with chondrosarcoma were enrolled in this retrospective study. Delay in diagnosis was defined as the period between initial clinical symptoms and histopathological diagnosis at our center. The delays were categorized as patient- or doctor-related. Short total delays were defined as <4 months; prolonged delays >4 months were assumed to have prognostic relevance.
resultsTotal delay in diagnosis was 688.0 days in patients with chondrosarcoma, which is significantly longer than the 163.3 days for osteosarcoma (P < 0.01) and 160.2 days for Ewing sarcoma (P < 0.01). Most doctor-related delays were at the pre-hospital stage, occurring at the general practitioner (GP)'s office. However, prolonged total delays (≥4 months) did not result in lower survival rates. Five-year-overall survival rates were 67.0% for osteosarcoma, 49.0% for Ewing sarcoma and 60.9% for chondrosarcoma. Survival was significantly lower for patients with metastatic disease for all three types of sarcoma.
conclusionProlonged delay in diagnosis does not result in lower survival. Metastatic disease has a pronounced effect on survival. Aggressive tumor behavior results in shorter delays. Minimizing GP-related delays could be achieved by adopting a lower threshold for obtaining plain radiographs at the pre-hospital stage.
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