Evidence map›Paper›PMID 27384614›Full record

ArticleAnnals of translational medicine2016

Association between microRNAs and coronary collateral circulation: is there a new role for the small non-coding RNAs?

Nikolaos Papageorgiou, Effimia Zacharia, Dimitris Tousoulis

Abstract readComment
In one paragraph

Article in Annals of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. International journal of molecular sciences · 2024
    Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Nikolaos Papageorgiou1 Barts Heart Centre, St Bartholomew's Hospital, London, UK ; 2 Department of Cardiology, Hippokration Hospital, University of Athens, Athens, Greece.
Effimia Zacharia1 Barts Heart Centre, St Bartholomew's Hospital, London, UK ; 2 Department of Cardiology, Hippokration Hospital, University of Athens, Athens, Greece.
Dimitris Tousoulis1 Barts Heart Centre, St Bartholomew's Hospital, London, UK ; 2 Department of Cardiology, Hippokration Hospital, University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We read with interest the article entitled "Circulating microRNAs characterizing patients with insufficient coronary collateral artery function" which was recently published in the PLOS ONE journal. It was demonstrated for the first time that specific circulating microRNAs (miRNAs) can distinguish patients with sufficient from those with insufficient coronary collateral circulation. Circulating miRNAs in the plasma of patients with stable CAD and chronic CTO could provide information with regard to the coronary collateral artery capacity. However, several aspects need to be taken into consideration before the use of miRNAs in the clinical practice. A risk model that would incorporate risk factors for cardiovascular disease and miRNAs could prove to be very useful. Although an association between the levels of miRNAs and the collateral artery capacity appears promising, it still does not confirm any causal role for miRNAs. Therefore, large clinical studies in populations with CTO are warranted to evaluate this finding.

Indexed as

angiogenesiscoronary artery collateralsmicroRNAs (miRNAs)

Identifiers

PMID27384614
PMCPMC4916350

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.