ReviewToxins2016
Ochratoxin A: 50 Years of Research.
Review in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
177 citing papers in PubMed, 3 syntheses or guidelines pooled it, 453 citations in OpenAlex.
- Pooled it
- Potential role of ochratoxin A in Parkinson's disease: a systematic review of current evidence.Archives of toxicology · 2025Pooled it
- Human Biomonitoring of Mycotoxins in Blood, Plasma and Serum in Recent Years: A Review.Toxins · 2020Pooled it
- Impacts of Fungal Infection and Mycotoxin Contamination on Nutritional Quality and Safety of Protein-Rich Pulses.Food safety (Tokyo, Japan) · 2026Article
- Article
- Biomonitoring of Occupational Exposure to Mycotoxins Among Swine Farm Workers: An Italian Pilot Study.Toxics · 2026Article
- Mycoflora, mycotoxin exposure and cancer risk assessment inToxicology reports · 2026Article
- U.S. FDA Regulatory Monitoring of Ochratoxin A in Human Foods: 2008-2022.Food safety (Tokyo, Japan) · 2026Article
- Occurrence of Ochratoxin A in Edible Pig Tissues (Kidneys, Liver, Muscle and Fat) in Greece Determined by HPLC-FD.Toxins · 2026Article
- Article
- Detection of Penicillium-Toxins in Nuts Commercialized in Italy Through LC-MS/MS Analyses.Toxins · 2025Article
- Human biomonitoring of mycotoxins: key challenges and future directions.Mycotoxin research · 2025Review
- Strain-Dependent Variability in Ochratoxin A Production byMicroorganisms · 2025Article
- Pervasive food contaminant ochratoxin-A induces energy crisis: Mitochondrial dysfunction in human primary proximal tubule cells.Toxicology reports · 2025Article
- Article
- Article
- Selective Cytotoxicity of Ochratoxin A: Pro-Apoptotic Effects on Healthy Immune Cells Compared to Leukemia Cells.Molecules (Basel, Switzerland) · 2025Article
- Bioinformatic based protein-ochratoxin A screening studies and fabrication of a protein-based electrochemical sensor for specific detection of ochratoxin A in food samples.Mikrochimica acta · 2025Article
- Investigation of Ochratoxin A and Citrinin Occurrence in Medicinal Herbal Products from the Czech Market.Drug safety · 2025Article
- Article
117 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since ochratoxin A (OTA) was discovered, it has been ubiquitous as a natural contaminant of moldy food and feed. The multiple toxic effects of OTA are a real threat for human beings and animal health. For example, OTA can cause porcine nephropathy but can also damage poultries. Humans exposed to OTA can develop (notably by inhalation in the development of acute renal failure within 24 h) a range of chronic disorders such as upper urothelial carcinoma. OTA plays the main role in the pathogenesis of some renal diseases including Balkan endemic nephropathy, kidney tumors occurring in certain endemic regions of the Balkan Peninsula, and chronic interstitial nephropathy occurring in Northern African countries and likely in other parts of the world. OTA leads to DNA adduct formation, which is known for its genotoxicity and carcinogenicity. The present article discusses how renal carcinogenicity and nephrotoxicity cause both oxidative stress and direct genotoxicity. Careful analyses of the data show that OTA carcinogenic effects are due to combined direct and indirect mechanisms (e.g., genotoxicity, oxidative stress, epigenetic factors). Altogether this provides strong evidence that OTA carcinogenicity can also occur in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.