Evidence map›Paper›PMID 27384560›Full record

Trial reportInternational journal of molecular sciences2016

Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System.

Elvira Montañez-Heredia, Sofia Irízar, Pedro J Huertas, Esperanza Otero, Marta Del Valle, Isidro Prat, Macarena S Díaz-Gallardo, Macarena Perán, Juan A Marchal, María Del Carmen Hernandez-Lamas

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05579665 (Comparative Effectiveness of Platelet Rich Plasma), which is not on this map. Cited by 64 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 15 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05579665 phase1 / phase2completednot on this mapstarted 2022, after this paper: background citation

Comparative Effectiveness of Platelet Rich Plasma (PRP), Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell Culture (MSCs) Secretome and Hyaluronic Acid (HA) for the Treatment of Knee Osteoarthritis

TypeinterventionalSponsorUniversitas SriwijayaRan2022 to 2023Enrolled45ConditionsKnee OsteoarthritisArmsPlatelet-rich Plasma, Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell Culture (MSCs) Secretome, Low Molecular Weight Hyaluronic Acid
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 15 syntheses or guidelines pooled it, 134 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Elvira Montañez-HerediaDepartment of Orthopedic Surgery and Traumatology, Virgen de la Victoria University Hospital, Málaga E-29010, Spain. elvira0511@gmail.com.
Sofia IrízarDepartment of Orthopedic Surgery and Traumatology, Virgen de la Victoria University Hospital, Málaga E-29010, Spain. sofiairizar@gmail.com.
Pedro J HuertasDepartment of Orthopedic Surgery and Traumatology, Virgen de la Victoria University Hospital, Málaga E-29010, Spain. pedrojhuertascot@hotmail.com.
Esperanza OteroDepartment of Anestesiology. Pain's Treatment Unit. Virgen de la Victoria University Hospital, MálagaE-29010, Spain. espeotero@hotmail.com.
Marta Del ValleDepartment of Anestesiology. Pain's Treatment Unit. Virgen de la Victoria University Hospital, MálagaE-29010, Spain. martadelvalle75@hotmail.com.
Isidro PratMálaga Tissue Bank, Regional Blood Center, Málaga E-29009, Spain. isidro.prat.sspa@juntadeandalucia.es.
Macarena S Díaz-GallardoMálaga Tissue Bank, Regional Blood Center, Málaga E-29009, Spain. macarenas.diaz.sspa@juntadeandalucia.es.
Macarena PeránDepartment of Health Sciences, University of Jaén, Jaén E-23071, Spain. mperan@ujaen.es.
Juan A MarchalBiopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research, University of Granada, Granada E-18071, Spain. jmarchal@ugr.es.
María Del Carmen Hernandez-LamasMálaga Tissue Bank, Regional Blood Center, Málaga E-29009, Spain. carmen.hernandez.lamas.sspa@juntadeandalucia.es.
Hospital Clínico Universitario Virgen de la Victoria · ESUniversidad de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intra-articular injection of platelet-rich plasma (PRP) has been established as a suitable treatment for knee osteoarthritis. Here, we present a double-blind randomized controlled clinical trial, conducted in a public Hospital of the Spanish National Health Care System, to evaluate the efficacy of injecting autologous PRP versus hyaluronic acid (HA) in knee osteoarthritis. PRP was manufactured in Malaga's Regional Blood Center (Spain). Patients that met the eligibility criteria were randomized into a PRP group or a HA group. Pain and functional improvements were assessed pre- and post-treatment (three and six months follow-up) using the Visual Analogue Scale (VAS); the Knee and Osteoarthritis Outcome System (KOOS) scale and the European Quality of Life scale (EUROQOL). Both groups presented pain reduction at six months. The VAS scores for the PRP group improved by at least 50% from their initial value, particularly at three months following the final infiltration, with results resembling those of the HA group at six months. PRP was more effective in patients with lower osteoarthritis grades. Both treatments improved pain in knee osteoarthritis patients without statistically significant differences between them. However, PRP injection was proved to improve pain three months after the final infiltration and to be more effective in lower osteoarthritis grades.

Indexed as

Platelet-Rich PlasmaAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansHyaluronic AcidInjections, Intra-ArticularMaleMiddle AgedOsteoarthritis, KneePainSpainTime FactorsHyaluronic Acidclinical trialhyaluronic acidknee osteoarthritisplatelet-rich plasma

Identifiers

PMID27384560
PMCPMC4964440
OpenAlexW2464119509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.