ArticleMolecules (Basel, Switzerland)2016
Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Nanofunctionalized Microparticles for Glucose Delivery in Three-Dimensional Cell Assemblies.ACS applied materials & interfaces · 2024Article
- In vitro anti-inflammatory activity and ameliorative effects on gastric ulcers of Licania rigida benth seed extract.Inflammopharmacology · 2023Article
- Investigating PLGA microparticle swelling behavior reveals an interplay of expansive intermolecular forces.Scientific reports · 2021Article
- Synthesis and biological evaluation of β-lapachone and nor-β-lapachone complexes with 2-hydroxypropyl-β-cyclodextrin as trypanocidal agents.Journal of bioenergetics and biomembranes · 2020Article
- NQO1 is Required for β-Lapachone-Mediated Downregulation of Breast-Cancer Stem-Cell Activity.International journal of molecular sciences · 2018Article
- Recent advances of controlled drug delivery using microfluidic platforms.Advanced drug delivery reviews · 2018Review
- The Effect of Fluid Shear Stress on the In Vitro Release Kinetics of Sirolimus from PLGA Films.Polymers · 2017Article
- Encapsulation of nor-β-lapachone into poly(d,l)-lactide-MedChemComm · 2017Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostate cancer is one of the most common malignant tumors in males and it has become a major worldwide public health problem. This study characterizes the encapsulation of Nor-β-lapachone (NβL) in poly(d,l-lactide-co-glycolide) (PLGA) microcapsules and evaluates the cytotoxicity of the resulting drug-loaded system against metastatic prostate cancer cells. The microcapsules presented appropriate morphological features and the presence of drug molecules in the microcapsules was confirmed by different methods. Spherical microcapsules with a size range of 1.03 ± 0.46 μm were produced with an encapsulation efficiency of approximately 19%. Classical molecular dynamics calculations provided an estimate of the typical adsorption energies of NβL on PLGA. Finally, the cytotoxic activity of NβL against PC3M human prostate cancer cells was demonstrated to be significantly enhanced when delivered by PLGA microcapsules in comparison with the free drug.
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