ArticleEuropean journal of heart failure2016
Pulmonary hypertension and pregnancy outcomes: data from the Registry Of Pregnancy and Cardiac Disease (ROPAC) of the European Society of Cardiology.
Article in European journal of heart failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers, 3 of them syntheses that pooled it.
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Who cites it
73 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pregnancy conditions and outcomes of Chinese women with mild, moderate and severe pulmonary arterial hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Pooled it
- How severity and classification of pulmonary hypertension affect pregnancy outcomes: a systematic review and timeline.International journal of obstetric anesthesia · 2024Pooled it
- Pregnancy feasibility in women with mild pulmonary arterial hypertension: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- Pulmonary hypertension in pregnancy: hemodynamic challenges, maternal risk, and multidisciplinary management.Journal of cardiovascular imaging · 2026Review
- Maternal and fetal outcomes in patients with congenital heart disease associated with pulmonary arterial hypertension in high-altitude areas: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Emergency cesarean section in pregnant women with severe pulmonary hypertension: the potential role of extracorporeal life support.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- The Obstetric Comorbidity Index (OB-CMI) and its association with ICU admission and length of hospital stay in pregnant patients with pulmonary hypertension: a retrospective cohort study (1996-2025).International journal of obstetric anesthesia · 2025Article
- Management of Pulmonary Hypertension in Pregnancy.Current heart failure reports · 2025Review
- Society for Maternal-Fetal Medicine Consult Series #73: Diagnosis and management of right and left heart failure during pregnancy and postpartum.Pregnancy (Hoboken, N.J.) · 2025Article
- Successful Vaginal Birth in Severe Idiopathic Pulmonary Arterial Hypertension: Lessons Learned From a Cardio-Obstetric Challenge.JACC. Case reports · 2025Article
- Maternal and neonatal outcomes in pregnancies complicated with pulmonary hypertension: a retrospective cohort study.European journal of medical research · 2025Article
- Pregnancy in patients with pulmonary hypertension: a systematic review and meta-analysis with meta-regression.Journal of thoracic disease · 2025Article
- Delivery in a Pregnant Woman With Pulmonary Arterial Hypertension (PAH): A Case Report.Cureus · 2025Article
- Analysis of Clinical Characteristics of 54 Dead Pregnant Patients With Pulmonary Hypertension.Pulmonary circulation · 2025Article
- The multidisciplinary management of pulmonary arterial hypertension patients in pregnancy and postpartum: A case series.American heart journal plus : cardiology research and practice · 2025Article
- Long-term maternal and fetal outcomes of pulmonary hypertension in pregnancy in the southwest plateau area of China: a retrospective study.BMC pulmonary medicine · 2025Article
- Clinical outcomes of pregnancy in patients with pulmonary hypertension: A single center observational study.Journal of cardiothoracic surgery · 2025Observational
- Cardiovascular-obstetric state-of-the-art review: pulmonary hypertension in pregnancy.Singapore medical journal · 2025Review
- Maternal heart failure: state-of-the-art review.Heart failure reviews · 2025Review
- Pregnancy and pulmonary artery hypertension: Management challenges.International journal of cardiology. Congenital heart disease · 2025Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo describe the outcomes of pregnancy in women with pulmonary hypertension. METHODS AND
resultsIn 2007 the European Registry on Pregnancy and Heart Disease was initiated by the European Society of Cardiology. Consecutive patients with all forms of cardiovascular disease, presenting with pregnancy, were enrolled with the aim of investigating the pregnancy outcomes. This subgroup of the cohort included 151 women with pulmonary hypertension (PH) either diagnosed by right heart catheterization or diagnosed as possible PH by echocardiographic signs, with 26% having pulmonary arterial hypertension (PAH), in three subgroups: idiopathic (iPAH), associated with congenital heart disease (CHD-PAH), or associated with other disease (oPAH), and 74% having PH caused by left heart disease (LHD-PH, n = 112). Maternal mean age was 29.2 ± 5.6 years and 37% were nulliparous. Right ventricular systolic pressure was <50 mmHg in 59.6% of patients, 50-70 mmHg in 28.5% and >70 mmHg in 11.9%. In more than 75% of patients, the diagnosis of PH had been made before pregnancy. Maternal death up to 1 week after delivery occurred in five patients (3.3%), with another two out of 78 patients who presented for follow-up (2.6%), dying within 6 months after delivery. The highest mortality was found in iPAH (3/7, 43%). During pregnancy, heart failure occurred in 27%. Caesarean section was performed in 63.4% (23.9% as emergency). Therapeutic abortion was performed in 4.0%. Complications included miscarriage (5.6%), fetal mortality (2%), premature delivery (21.7%), low birth weight (19.0%), and neonatal mortality (0.7%).
conclusionMortality in this group of patients with various forms of PH was lower than previously reported as specialized care during pregnancy and delivery was available. However, maternal and fetal mortality remains prohibitively high in women with iPAH, although this conclusion is restricted by limited numbers. Early advice on contraception, pregnancy risk and fetal outcome remains paramount.
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