Evidence map›Paper›PMID 27384423›Full record

ArticleEnvironmental health perspectives2017

Pesticides are Associated with Allergic and Non-Allergic Wheeze among Male Farmers.

Jane A Hoppin, David M Umbach, Stuart Long, Stephanie J London, Paul K Henneberger, Aaron Blair, Michael Alavanja, Laura E Beane Freeman, Dale P Sandler

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 133 citations in OpenAlex.

  1. Article
  2. Herbicide-related health risks: key mechanisms and a guide to mitigation strategies.Journal of occupational medicine and toxicology (London, England) · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Current-use pesticide exposures in remote Inuit communities.International journal of circumpolar health · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Adhesion Molecules in Lung Inflammation from Repeated Glyphosate Exposures.International journal of environmental research and public health · 2023
    Article
  14. Article
  15. Article
  16. Influence of Rural Environmental Factors in Asthma.Immunology and allergy clinics of North America · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Direct Effects of Glyphosate onFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Jane A HoppinDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
David M Umbach
Stuart Long
Stephanie J London
Paul K Henneberger
Aaron Blair
Michael Alavanja
Laura E Beane Freeman
Dale P Sandler
United States Department of Health and Human Services · USTriangle · USCenters for Disease Control and Prevention · USNational Institutes of Health · USNorth Carolina State University · USWestat (United States) · US

Funding

Studies of Occupational Cancer (Pesticides)ZIACP010119 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI BEANE FREEMAN, LAURA · 2009 to 2025
$46.1M
Health Effects Of Exposures In AgricultureZIAES049030 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2025
$11.2M
Genetics and Environment in Adult Respiratory, Allergic and Cardiac diseaseZIAES043012 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.4M
Lung Health Study in the Agricultural Health StudyZIAES102385 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.1M
STUDIES OF OCCUPATIONAL CANCER--PESTICIDESZ01CP010119 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALAVANJA, MICHAEL · 1996 to 2008
$5.0M
INDOOR ALLERGENS AND ASTHMAZ01ES025041 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 1998 to 2008
$1.9M
Statistical techniques applied to environmental health sciencesZIAES103126 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI UMBACH, DAVID M · 2012 to 2025
$1.0M
Intramural NIH HHS Z01 CP010119Intramural NIH HHS Z01 ES025041
6 · The paper itself

Abstract

backgroundGrowing evidence suggests that pesticide use may contribute to respiratory symptoms.

objectiveWe evaluated the association of currently used pesticides with allergic and non-allergic wheeze among male farmers.

methodsUsing the 2005-2010 interview data of the Agricultural Health Study, a prospective study of farmers in North Carolina and Iowa, we evaluated the association between allergic and non-allergic wheeze and self-reported use of 78 specific pesticides, reported by ≥ 1% of the 22,134 men interviewed. We used polytomous regression models adjusted for age, BMI, state, smoking, and current asthma, as well as for days applying pesticides and days driving diesel tractors. We defined allergic wheeze as reporting both wheeze and doctor-diagnosed hay fever (

resultsIn models evaluating current use of specific pesticides, 19 pesticides were significantly associated (

conclusionsThese results for farmers implicate several pesticides that are commonly used in agricultural and residential settings with adverse respiratory effects.

Indexed as

PesticidesRespiratory SoundsAdultAgricultural Workers' DiseasesAgricultureFarmersHumansIowaMaleNorth CarolinaOccupational ExposureProspective StudiesPesticides

Identifiers

PMID27384423
PMCPMC5381985
OpenAlexW2471044357

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.