SynthesisClinical drug investigation2016
Cholinergic Antagonists Combined with Electrical Stimulation or Bladder Training Treatments for Overactive Bladder in Female Adults: A Meta-Analysis of Randomized Controlled Trials.
Synthesis in Clinical drug investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Efficacy of non-pharmacological interventions in patients with overactive bladder: A protocol for systematic review and network meta-analysis.Nursing open · 2022Article
- Advances in pharmacotherapy for the treatment of overactive bladder.Current bladder dysfunction reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveThe therapeutic effects of cholinergic antagonists combined with non-drug therapy compared with cholinergic antagonist therapy alone for overactive bladder in adult women are unclear. Thus, we conducted a meta-analysis of randomized controlled trials to compare the therapeutic effects of cholinergic antagonists plus non-drug therapy (electrical stimulation and bladder training) with cholinergic antagonist therapy alone among female overactive bladder patients.
methodsPertinent studies were identified by searching PubMed, Web of Science, and the Chinese Biological Medicine databases to May 31, 2016. Study-specific standardized mean differences were combined using fixed- or random-effects models depending on whether significant heterogeneity was detected.
resultsTen randomized controlled trials were identified. A total of 485 female overactive bladder patients were treated with the combined therapy and 497 were treated with the cholinergic antagonists alone. For the cholinergic antagonists combined with electrical stimulation treatment compared with cholinergic antagonist therapy alone, there were statistically significant reductions of average frequency of urination, incontinence, and urgency, with pooled standardized mean differences of -2.38, -1.32, and -0.87, respectively. There was also a statistically significant reduction of average frequency of urination (pooled standardized mean difference = - 0.30; 95 % confidence interval: -0.52 to -0.08) for the cholinergic antagonists combined with bladder training treatment compared with cholinergic antagonist therapy alone.
conclusionThis study indicated that female overactive bladder patients with cholinergic antagonists combined with electrical stimulation or bladder training treatment may lower the average frequency of urination, incontinence, and urgency when compared with those who received isolated drug therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.