ArticleCritical care (London, England)2016
Acute kidney injury: from clinical to molecular diagnosis.
Article in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic value of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for acute kidney injury: a meta-analysis.Critical care (London, England) · 2017Pooled it
- Trial
- Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial.Intensive care medicine · 2017Trial
- Early Diagnostic and Prognostic Value of the Urinary TIMP-2 and IGFBP-7 in Acute Kidney Injury in Critically Ill Children.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Epithelial cell states associated with kidney and allograft injury.Nature reviews. Nephrology · 2024Review
- Mitochondrial Oxidative Metabolism: An Emerging Therapeutic Target to Improve CKD Outcomes.Biomedicines · 2023Review
- Serum and urinary angiotensinogen levels as prognostic indicators in acute kidney injury: a prospective study.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department.Medicina (Kaunas, Lithuania) · 2022Observational
- The impact of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury on mortality and clinical outcomes: a meta-analysis.Clinical kidney journal · 2022Article
- Burn-Induced Acute Kidney Injury-Two-Lane Road: From Molecular to Clinical Aspects.International journal of molecular sciences · 2022Review
- The Urinary Level of Injury Biomarkers Is Not Univocally Reflective of the Extent of Toxic Renal Tubular Injury in Rats.International journal of molecular sciences · 2022Article
- Derivation and validation of urinary TIMP-1 for the prediction of acute kidney injury and mortality in critically ill children.Journal of translational medicine · 2022Article
- Association between Inflammation-Based Parameters and Prognosis in Patients with Acute Kidney Injury.Medicina (Kaunas, Lithuania) · 2021Article
- Article
- The relationship between intra-parenchymal renal resistive index variation and renal functional reserve in healthy subjects.Journal of nephrology · 2021Article
- Astaxanthin protects against early acute kidney injury in severely burned rats by inactivating the TLR4/MyD88/NF-κB axis and upregulating heme oxygenase-1.Scientific reports · 2021Article
- Plasma Endogenous Sulfur Dioxide: A Novel Biomarker to Predict Acute Kidney Injury in Critically Ill Patients.International journal of general medicine · 2021Article
- [New kidney function tests: Renal functional reserve and furosemide stress test].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Review
- Evaluating NephrocheckInternational journal of nephrology and renovascular disease · 2020Review
- Proenkephalin a 119-159 (penKid) - a novel biomarker for acute kidney injury in sepsis: an observational study.BMC emergency medicine · 2019Observational
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Abstract
The RIFLE classification was introduced in 2004 to describe the presence of acute kidney injury (AKI) and to define its clinical stage, based upon the serum creatinine level and urine output. The same criteria, although slightly modified, are used in the other scoring systems AKIN and KDIGO. Mortality and morbidity remain high in AKI, suggesting that current diagnostic methods are suboptimal, poorly accurate, and often timely inadequate in detecting the presence of early kidney injury. Conversely, a growing body of evidence indicates that new AKI biomarkers can be used to both rule out AKI and to assess high-risk conditions or the presence of subclinical forms. Neutrophil gelatinase-associated lipocalin or cell cycle arrest biomarkers seem to be sensitive and specific enough to be used in conjunction with existing markers of AKI for better classifying renal injury as well as dysfunction. Improvements in diagnosis, risk identification, stratification, prognosis, and therapeutic monitoring may improve prevention and protection from organ damage and help to identify patients at risk, allowing individualized therapy. In this view, we may say that AKI diagnosis has finally moved from clinical to molecular level with potential benefits for the patients because similar progress has been shown in other disciplines.
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