ArticleScientific reports2016
Molecular evolution of the capsid gene in human norovirus genogroup II.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
- Integrated in-silico design and in vivo validation of multi-epitope vaccines for norovirus.Virology journal · 2025Article
- Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase (Microorganisms · 2025Article
- Molecular Evolutionary Analyses of the Spike Protein Gene and Spike Protein in the SARS-CoV-2 Omicron Subvariants.Microorganisms · 2023Article
- Predicting Dominant Genotypes in Norovirus Seasons in Japan.Life (Basel, Switzerland) · 2023Article
- Article
- Epidemiology and genetic diversity of norovirus GII genogroups among children in Hubei, China, 2017-2019.Virologica Sinica · 2023Article
- Molecular and Genetics-Based Systems for Tracing the Evolution and Exploring the Mechanisms of Human Norovirus Infections.International journal of molecular sciences · 2023Review
- Article
- Article
- Simultaneous detection of human norovirus GI, GII and SARS-CoV-2 by a quantitative one-step triplex RT-qPCR.Frontiers in microbiology · 2023Article
- Genomic stratification and differential natural selection signatures among human norovirus genogroup II isolates.Archives of virology · 2022Article
- Norovirus GII.2[P16] strain in Shenzhen, China: a retrospective study.BMC infectious diseases · 2021Article
- Evolution of the GII.3[P12] Norovirus from 2010 to 2019 in Jiangsu, China.Gut pathogens · 2021Article
- Linear B-Cell Epitopes in Human Norovirus GII.4 Capsid Protein Elicit Blockade Antibodies.Vaccines · 2021Article
- Molecular Evolution of Human Norovirus GII.2 Clusters.Frontiers in microbiology · 2021Article
- Molecular evolution of the capsid (Heliyon · 2020Article
- Increasing Recombinant Strains Emerged in Norovirus Outbreaks in Jiangsu, China: 2015-2018.Scientific reports · 2019Article
- Molecular Evolution of Classic Human Astrovirus, as Revealed by the Analysis of the Capsid Protein Gene.Viruses · 2019Article
- Molecular Evolution of the Protease Region in Norovirus Genogroup II.Frontiers in microbiology · 2019Article
- Variation of human norovirus GII genotypes detected in Ibaraki, Japan, during 2012-2018.Gut pathogens · 2019Article
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Authors and funding
22 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capsid protein of norovirus genogroup II (GII) plays crucial roles in host infection. Although studies on capsid gene evolution have been conducted for a few genotypes of norovirus, the molecular evolution of norovirus GII is not well understood. Here we report the molecular evolution of all GII genotypes, using various bioinformatics techniques. The time-scaled phylogenetic tree showed that the present GII strains diverged from GIV around 1630CE at a high evolutionary rate (around 10(-3) substitutions/site/year), resulting in three lineages. The GII capsid gene had large pairwise distances (maximum > 0.39). The effective population sizes of the present GII strains were large (>10(2)) for about 400 years. Positive (20) and negative (over 450) selection sites were estimated. Moreover, some linear and conformational B-cell epitopes were found in the deduced GII capsid protein. These results suggested that norovirus GII strains rapidly evolved with high divergence and adaptation to humans.
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