ArticleWorld journal of surgery2016
Selective Parathyroid Hormone Venous Sampling in Patients with Persistent or Recurrent Primary Hyperparathyroidism and Negative, Equivocal or Discordant Noninvasive Imaging.
Article in World journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Preoperative imaging strategies to optimize surgical treatment in primary hyperparathyroidism (pHPT).BMC surgery · 2026Article
- Mediastinal parathyroid adenoma: diagnostic and therapeutic challenges.Mediastinum (Hong Kong, China) · 2026Review
- Preoperative Lateralization and Diagnostic Value of Selective Bilateral Internal Jugular Venous Sampling in Primary Hyperparathyroidism: Single-Center Experience.Medicina (Kaunas, Lithuania) · 2024Article
- Invasive Testing for Preoperative Localization of Parathyroid Tumors.Journal of the Endocrine Society · 2023Article
- Tricks of the trade: Techniques for preoperative localization in reoperative parathyroidectomy.American journal of surgery · 2023Article
- Quantitative application of dual-phase 99mTc-sestamibi SPECT/CT imaging of parathyroid lesions: identification of optimal timing in secondary hyperparathyroidism.EJNMMI physics · 2023Article
- Parathyroid venous sampling for the preoperative localisation of parathyroid adenoma in patients with primary hyperparathyroidism.Scientific reports · 2022Article
- Selective venous sampling in primary hyperparathyroidism: Is it worth doing?Turkish journal of medical sciences · 2022Article
- Evaluation of diagnostic efficacy for localization of parathyroid adenoma in patients with primary hyperparathyroidism undergoing repeat surgery.Langenbeck's archives of surgery · 2021Article
- Review
- WillEndocrine · 2021Review
- Selection of parathyroidectomy methods for primary hyperparathyroidism according to concordance between ultrasonography and MIBI scan results.Gland surgery · 2021Article
- Recurrent primary hyperparathyroidism: a diagnostic and management dilemma.Endocrinology, diabetes & metabolism case reports · 2021Article
- Evaluation of an optimal cutoff of parathyroid venous sampling gradient for localizing primary hyperparathyroidism.Journal of bone and mineral metabolism · 2020Article
- Localization of Parathyroid Disease in Reoperative Patients with Primary Hyperparathyroidism.International journal of endocrinology · 2020Review
- Selective venous sampling supports localization of adenoma in primary hyperparathyroidism.Acta radiologica open · 2018Article
- Queries and Comments on the Current Role of "Selective Parathyroid Venous Sampling in Patients with Persistent or Recurrent Primary Hyperparathyroidism and Negative, Equivocal or Discordant Noninvasive Imaging".World journal of surgery · 2017Article
- Persistent and recurrent hyperparathyroidism.Updates in surgery · 2017Review
- Article
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8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients with persistent (P-PHPT) or recurrent (R-PHPT) primary hyperparathyroidism, preoperative localization is important. Selective parathyroid hormone venous sampling (sPVS) is an invasive technique that can be used to regionalize and/or lateralize the source of PHPT when noninvasive imaging studies are nonlocalizing. The aim of the present study was to assess the role of sPVS in the preoperative evaluation of patients with P-PHPT or R-PHPT and negative, equivocal, or discordant noninvasive imaging localization.
methodsAfter IRB-approval a retrospective review of all patients with P-PHPT or R-PHPT and nonlocalizing noninvasive imaging that underwent sPVS from 2000 to 2014 was performed. The location of the source of PHPT at sPVS was predicted by a parathyroid hormone (PTH) gradient and compared to the surgical, pathology, and biochemical follow-up data as the gold standard. Sensitivity and positive predictive value (PPV) were calculated.
resultsOf 30 patients who underwent sPVS, 12 patients did not undergo surgical exploration due to negative or non-localizing PTH gradient (n = 8) or opted for medical management (n = 4). Of the 18 patients who underwent surgical exploration, 17 (94 %) had a positive PTH gradient and pathologic parathyroid tissue identified at surgery. Sensitivity and PPV of sPVS were 93 and 77 %, respectively, for all surgical cases, 86 and 60.0 % for cervical cases (n = 11), and 100 and 100 % for mediastinal cases (n = 7). Sixteen patients (89 %) were surgically cured.
conclusionsIn patients with P-PHPT or R-PHPT and nonlocalizing imaging studies, sPVS is a sensitive test for localizing the source of PHPT when a positive PTH gradient is present.
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