ArticleCancer research and treatment2017
Paired Primary and Metastatic Tumor Analysis of Somatic Mutations in Synchronous and Metachronous Colorectal Cancer.
Article in Cancer research and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Analysis of Shared Variants between Cancer Biospecimens.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Mutation characteristics and molecular evolution of ovarian metastasis from gastric cancer and potential biomarkers for paclitaxel treatment.Nature communications · 2024Article
- The different clonal origins of metachronous and synchronous metastases.Journal of cancer research and clinical oncology · 2023Article
- Article
- Prognostic factors of BRAF V600E colorectal cancer with liver metastases: a retrospective multicentric study.World journal of surgical oncology · 2022Article
- InoperableMolecular and clinical oncology · 2022Article
- Clinicopathological and molecular features between synchronous and metachronous metastases in colorectal cancer.American journal of cancer research · 2021Article
- Genetic Alterations of Metastatic Colorectal Cancer.Biomedicines · 2020Review
- Case report: recurrent pituitary adenoma has increased load of somatic variants.BMC endocrine disorders · 2020Article
- Microsatellite Instability: Diagnosis, Heterogeneity, Discordance, and Clinical Impact in Colorectal Cancer.Cancers · 2019Review
- Article
- Heterogeneity in Colorectal Cancer: A Challenge for Personalized Medicine?International journal of molecular sciences · 2018Review
- Association of BRAF Mutations With Survival and Recurrence in Surgically Treated Patients With Metastatic Colorectal Liver Cancer.JAMA surgery · 2018Article
- Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.Medical sciences (Basel, Switzerland) · 2018Review
- Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting.Cancer metastasis reviews · 2018Review
- Differences in clinical characteristics and mutational pattern between synchronous and metachronous colorectal liver metastases.Cancer management and research · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough the mutation status of MATERIALS AND
methodsIn this study, 41 genes were evaluated and the mutational profiles were compared in 46 colorectal cancer patients with paired surgical specimens of primary and metastatic lesions: synchronous (n=27) and metachronous (n=19) lesions. A high-throughput mass spectrometry-based genotyping platform validated by orthogonal chemistry, OncoMap v.4.4, was used to evaluate the formalin-fixed, paraffin-embedded surgical specimens. The patients' demographics, tumor characteristics, and microsatellite instability status were analyzed by a retrospective chart review.
resultsIn this study,with OncoMap, mutationswere identified in 80.4% of patientswith the following frequency:
conclusionThese findings indicate the major pathway genes, including
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