ArticleScientific reports2016
Caenorhabditis elegans employs innate and learned aversion in response to bacterial toxic metabolites tambjamine and violacein.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
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- Making "Sense" of Ecology from a Genetic Perspective:Metabolites · 2022Review
- Multi-target drug with potential applications: violacein in the spotlight.World journal of microbiology & biotechnology · 2021Review
- Consumption of Oleic Acid During Matriphagy in Free-Living Nematodes Alleviates the Toxic Effects of the Bacterial Metabolite Violacein.Scientific reports · 2020Article
- The Role of Neurotransmitters in the Protection ofFrontiers in cellular and infection microbiology · 2020Article
- Diversity and Distribution of Bacteria Producing Known Secondary Metabolites.Microbial ecology · 2019Article
- The structure and function of pathogen disgust.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Olfactory experience primes the heat shock transcription factor HSF-1 to enhance the expression of molecular chaperones inScience signaling · 2017Article
- An oxytocin-dependent social interaction between larvae and adult C. elegans.Scientific reports · 2017Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
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Abstract
Bacteriovorus eukaryotes such as nematodes are one of the major natural predators of bacteria. In their defense bacteria have evolved a number of strategies to avoid predation, including the production of deterrent or toxic metabolites, however little is known regarding the response of predators towards such bacterial defenses. Here we use the nematode C. elegans as a model to study a predators' behavioral response towards two toxic bacterial metabolites, tambjamine YP1 and violacein. We found that C. elegans displays an innate avoidance behavior towards tambjamine YP1, however requires previous exposure to violacein before learning to avoid this metabolite. The learned avoidance of violacein is specific, reversible, is mediated via the nematode olfactory apparatus (aversive olfactory learning) and is reduced in the absence of the neurotransmitter serotonin. These multiple strategies to evade bacterial toxic metabolites represent a valuable behavioral adaptation allowing bacteriovorus predators to distinguish between good and bad food sources, thus contributing to the understanding of microbial predator-prey interactions.
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