Evidence map›Paper›PMID 27384027›Full record

ReviewGenetics2016

Learning to Fish with Genetics: A Primer on the Vertebrate Model Danio rerio.

Nathalia G Holtzman, M Kathryn Iovine, Jennifer O Liang, Jacqueline Morris

Open access · bronzeAbstract readReview
In one paragraph

Review in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Human-specific gene expansions contribute to brain evolution.bioRxiv : the preprint server for biology · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. zMADM (zebrafish mosaic analysis with double markers) for single-cell gene knockout and dual-lineage tracing.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
  11. Article
  12. Hair cell toxicology: With the help of a little fish.Frontiers in cell and developmental biology · 2022
    Review
  13. Cerebrovascular development: mechanisms and experimental approaches.Cellular and molecular life sciences : CMLS · 2021
    Review
  14. Review
  15. Review
  16. Recent Application of Zebrafish Models in Atherosclerosis Research.Frontiers in cell and developmental biology · 2021
    Review
  17. Forward genetic approach for behavioral neuroscience using animal models.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2020
    Article
  18. Cell Kinetics in the Adult Neurogenic Niche and Impact of Diet-Induced Accelerated Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Nathalia G HoltzmanDepartment of Biology, Queens College, and The Graduate Center, City University of New York, New York 10016.
M Kathryn IovineDepartment of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015.
Jennifer O LiangDepartment of Biology, University of Minnesota Duluth, Minnesota 55812 joliang@d.umn.edu.
Jacqueline MorrisDepartment of Biology and Geology, Baldwin Wallace University, Berea, Ohio 44017.
Baldwin–Wallace College · USLehigh University · USQueens College, CUNY · USUniversity of Minnesota, Duluth · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last 30 years, the zebrafish has become a widely used model organism for research on vertebrate development and disease. Through a powerful combination of genetics and experimental embryology, significant inroads have been made into the regulation of embryonic axis formation, organogenesis, and the development of neural networks. Research with this model has also expanded into other areas, including the genetic regulation of aging, regeneration, and animal behavior. Zebrafish are a popular model because of the ease with which they can be maintained, their small size and low cost, the ability to obtain hundreds of embryos on a daily basis, and the accessibility, translucency, and rapidity of early developmental stages. This primer describes the swift progress of genetic approaches in zebrafish and highlights recent advances that have led to new insights into vertebrate biology.

Indexed as

Models, AnimalAnimalsGene Expression RegulationOrganogenesisRegenerationZebrafish

Identifiers

PMID27384027
PMCPMC4937470
OpenAlexW2469053820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.