Evidence map›Paper›PMID 27384026›Full record

ReviewGenetics2016

Chromosome Duplication in Saccharomyces cerevisiae.

Stephen P Bell, Karim Labib

Open access · bronzeAbstract readReview
In one paragraph

Review in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 255 papers.

0numbers the graph read from it
0cells of the map it votes in
255citing papers in PubMed
23.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

255 citing papers in PubMed, 403 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Genome sequence assembly and annotation ofNAR genomics and bioinformatics · 2025
    Article
  19. An Orc6 tether mediates ORC binding-site switching during replication origin licensing.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

195 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Stephen P BellHoward Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 kpmlabib@dundee.ac.uk spbell@mit.edu.ORCID http://orcid.org/0000-0002-2876-610X
Karim LabibMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, DD1 5EH, United Kingdom kpmlabib@dundee.ac.uk spbell@mit.edu.
Howard Hughes Medical Institute · USMedical Research Council · GB

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Paula T Hammond · 1985 to 2026
$93.9M
INITIATION OF DNA REPLICATION OF YEAST CHROMOSOMESR01GM052339 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P. · 1995 to 2019
$5.5M
Medical Research Council MC_UU_12016/13NCI NIH HHS P30 CA014051NIGMS NIH HHS R01 GM052339Wellcome Trust 102943Wellcome Trust 102943/Z/13/Z
6 · The paper itself

Abstract

The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic cells, the assembly of the multi-enzyme replisomes that perform replication is divided into stages that occur at distinct phases of the cell cycle. Replicative DNA helicases are loaded around origins of DNA replication exclusively during G1 phase. The loaded helicases are then activated during S phase and associate with the replicative DNA polymerases and other accessory proteins. The function of the resulting replisomes is monitored by checkpoint proteins that protect arrested replisomes and inhibit new initiation when replication is inhibited. The replisome also coordinates nucleosome disassembly, assembly, and the establishment of sister chromatid cohesion. Finally, when two replisomes converge they are disassembled. Studies in Saccharomyces cerevisiae have led the way in our understanding of these processes. Here, we review our increasingly molecular understanding of these events and their regulation.

Indexed as

ChromatidsChromosome DuplicationChromosomes, FungalDNA-Directed DNA PolymeraseDNA HelicasesDNA ReplicationSaccharomyces cerevisiaeS PhaseSpindle ApparatusDNA-Directed DNA PolymeraseDNA Helicasescell cyclechromatinchromosome duplicationDNA replicationgenome stabilityYeastBook

Identifiers

PMID27384026
PMCPMC4937469
OpenAlexW2473838984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.