Osteoarthritis: Bone as an imaging biomarker and treatment target in OA.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. DCLK1-dependent NF-κB activation mediates p-STAT3-induced osteoarthritis progression.Clinical and translational medicine · 2026
   Article
2. Causal association between bone mineral density and the risk of joint replacement in patients with osteoarthritis: a Mendelian randomization study.Clinical rheumatology · 2025
   Article
3. Bone marrow lesions in osteoarthritis: biomarker or treatment target? A narrative review.Skeletal radiology · 2025
   Review
4. Novel nomogram for predicting the progression of osteoarthritis based on 3D-MRI bone shape: data from the FNIH OA biomarkers consortium.BMC musculoskeletal disorders · 2021
   Article
5. Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk.Cell · 2020
   Article
6. Software comparison to analyze bone radiomics from high resolution CBCT scans of mandibular condyles.Dento maxillo facial radiology · 2019
   Article
7. Establishing outcome measures in early knee osteoarthritis.Nature reviews. Rheumatology · 2019
   Review
8. Disease modification in OA - will we ever get there?Nature reviews. Rheumatology · 2019
   Article
9. Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis.Annals of the rheumatic diseases · 2018
   Article

Corrections and comments

• Comment on
  The relationship between three-dimensional knee MRI bone shape and total knee replacement-a case control study: data from the Osteoarthritis Initiative.2016

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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