Evidence map›Paper›PMID 27383839›Full record

ReviewCellular and molecular neurobiology2017

Pathophysiology Associated with Traumatic Brain Injury: Current Treatments and Potential Novel Therapeutics.

Matthew L Pearn, Ingrid R Niesman, Junji Egawa, Atsushi Sawada, Angels Almenar-Queralt, Sameer B Shah, Josh L Duckworth, Brian P Head

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05386966 (Medicolegal Aspects of Head Trauma in Sohag University Hospitals), which is not on this map. Cited by 173 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05386966 unknown statusnot on this mapstarted 2022, after this paper: background citation

Medicolegal Aspects of Head Trauma in Sohag University Hospitals

TypeobservationalSponsorSohag UniversityRan2022 to 2023Enrolled250ConditionsHead TraumaArmsquestionnaire
3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Research progress on biomarkers of traumatic brain injury.Animal models and experimental medicine · 2026
    Review
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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew L PearnDepartment of Anesthesiology, Veterans Affairs San Diego Healthcare System, VA Medical Center 125, University of California, 3350 La Jolla Village Drive, San Diego, CA, 92161-5085, USA.
Ingrid R NiesmanDepartment of Cellular and Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA.
Junji EgawaDepartment of Anesthesiology, Veterans Affairs San Diego Healthcare System, VA Medical Center 125, University of California, 3350 La Jolla Village Drive, San Diego, CA, 92161-5085, USA.
Atsushi SawadaDepartment of Anesthesiology, Veterans Affairs San Diego Healthcare System, VA Medical Center 125, University of California, 3350 La Jolla Village Drive, San Diego, CA, 92161-5085, USA.
Angels Almenar-QueraltDepartment of Cellular and Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA.
Sameer B ShahUCSD Departments of Orthopaedic Surgery and Bioengineering, University of California, La Jolla, San Diego, CA, 92093, USA.
Josh L DuckworthDepartment of Neurology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.
Brian P HeadDepartment of Anesthesiology, Veterans Affairs San Diego Healthcare System, VA Medical Center 125, University of California, 3350 La Jolla Village Drive, San Diego, CA, 92161-5085, USA. bhead@ucsd.edu.

Funding

Neuronal-targeted caveolin-1 as a therapy for traumatic brain injuryR01NS073653 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEAD, BRIAN P · 2012 to 2015
$1.4M
The role of caveolin-1 on anesthetic-mediated neurotoxicityK08GM124500 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PEARN, MATTHEW L · 2018 to 2022
$1.0M
BLRD VA I01 BX001225NIGMS NIH HHS K08 GM124500NIGMS NIH HHS L40 GM125142NINDS NIH HHS R01 NS073653
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is one of the leading causes of death of young people in the developed world. In the United States alone, 1.7 million traumatic events occur annually accounting for 50,000 deaths. The etiology of TBI includes traffic accidents, falls, gunshot wounds, sports, and combat-related events. TBI severity ranges from mild to severe. TBI can induce subtle changes in molecular signaling, alterations in cellular structure and function, and/or primary tissue injury, such as contusion, hemorrhage, and diffuse axonal injury. TBI results in blood-brain barrier (BBB) damage and leakage, which allows for increased extravasation of immune cells (i.e., increased neuroinflammation). BBB dysfunction and impaired homeostasis contribute to secondary injury that occurs from hours to days to months after the initial trauma. This delayed nature of the secondary injury suggests a potential therapeutic window. The focus of this article is on the (1) pathophysiology of TBI and (2) potential therapies that include biologics (stem cells, gene therapy, peptides), pharmacological (anti-inflammatory, antiepileptic, progrowth), and noninvasive (exercise, transcranial magnetic stimulation). In final, the review briefly discusses membrane/lipid rafts (MLR) and the MLR-associated protein caveolin (Cav). Interventions that increase Cav-1, MLR formation, and MLR recruitment of growth-promoting signaling components may augment the efficacy of pharmacologic agents or already existing endogenous neurotransmitters and neurotrophins that converge upon progrowth signaling cascades resulting in improved neuronal function after injury.

Indexed as

AnimalsBlood-Brain BarrierBrain Injuries, TraumaticCaveolinsDisease Models, AnimalHumansInflammationTreatment OutcomeCaveolinsBiologicsBlood–brain barrierCaveolinMembrane/lipid raftsNeuroinflammationTraumatic brain injury

Identifiers

PMID27383839
PMCPMC11482200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.