ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Aging-Resilient Associations between the Arcuate Fasciculus and Vocabulary Knowledge: Microstructure or Morphology?
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 35 citations in OpenAlex.
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- The arcuate fasciculus: Combining structure and function into surgical considerations.Brain and behavior · 2023Review
- A narrative review of the anatomy and function of the white matter tracts in language production and comprehension.Frontiers in human neuroscience · 2023Review
- Cyto/myeloarchitecture of cortical gray matter and superficial white matter in early neurodevelopment: multimodal MRI study in preterm neonates.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Regional glucose metabolic decreases with ageing are associated with microstructural white matter changes: a simultaneous PET/MR study.European journal of nuclear medicine and molecular imaging · 2022Article
- The frontotemporal organization of the arcuate fasciculus and its relationship with speech perception in young and older amateur singers and non-singers.Human brain mapping · 2021Article
- Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Differences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults.Frontiers in aging neuroscience · 2021Article
- White matter disconnection is related to age-related phonological deficits.Brain imaging and behavior · 2020Article
- Intra- and interhemispheric white matter tract associations with auditory spatial processing: Distinct normative and aging effects.NeuroImage · 2020Article
- fMRI-guided white matter connectivity in fluid and crystallized cognitive abilities in healthy adults.NeuroImage · 2020Article
- Language development and brain reorganization in a child born without the left hemisphere.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- A browser-based tool for visualization and analysis of diffusion MRI data.Nature communications · 2018Article
- Orthographic influence on spoken word identification: Behavioral and fMRI evidence.Neuropsychologia · 2018Article
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6 authors at 3 institutions in 1 country.
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Abstract
unlabelledVocabulary knowledge is one of the few cognitive functions that is relatively preserved in older adults, but the reasons for this relative preservation have not been well delineated. We tested the hypothesis that individual differences in vocabulary knowledge are influenced by arcuate fasciculus macrostructure (i.e., shape and volume) properties that remain stable during the aging process, rather than white matter microstructure that demonstrates age-related declines. Vocabulary was not associated with age compared to pronounced age-related declines in cognitive processing speed across 106 healthy adults (19.92-88.29 years) who participated in this neuroimaging experiment. Fractional anisotropy in the left arcuate fasciculus was significantly related to individual variability in vocabulary. This effect was present despite marked age-related differences in a T1-weighted/T2-weighted ratio (T1w/T2w) estimate of myelin that were observed throughout the left arcuate fasciculus and associated with age-related differences in cognitive processing speed. However, atypical patterns of arcuate fasciculus morphology or macrostructure were associated with decreased vocabulary knowledge. These results suggest that deterioration of tissue in the arcuate fasciculus occurs with normal aging, while having limited impact on tract organization that underlies individual differences in the acquisition and retrieval of lexical and semantic information. SIGNIFICANCE STATEMENT: Vocabulary knowledge is resilient to widespread age-related declines in brain structure that limit other cognitive functions. We tested the hypothesis that arcuate fasciculus morphology, which supports the development of reading skills that bolster vocabulary, could explain this relative preservation. We disentangled (1) the effects of age-related declines in arcuate microstructure (mean diffusivity; myelin content estimate) that predicted cognitive processing speed but not vocabulary, from (2) relatively stable arcuate macrostructure (shape/volume) that explained significant variance in an age-independent association between fractional anisotropy and vocabulary. This latter result may reflect differences in fiber trajectory and organization that are resilient to aging. We propose that developmental sculpting of the arcuate fasciculus determines acquisition, storage, and access of lexical information across the adult lifespan.
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