Evidence map›Paper›PMID 27383397›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2016

Lanthanide Hydroxide Nanoparticles Induce Angiogenesis via ROS-Sensitive Signaling.

Haishan Zhao, Olivia J Osborne, Sijie Lin, Zhaoxia Ji, Robert Damoiseux, Yuqiang Wang, André E Nel, Shuo Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  6. Article
  7. Article
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  9. Article
  10. Article
  11. Review
  12. Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  13. Review
  14. Biomedicines · 2021
    Article
  15. Review
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  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haishan ZhaoCollege of Pharmacy, Jinan University, Guangzhou, Guangdong, 510640, China.
Olivia J OsborneCenter for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Sijie LinCollege of Environmental Science and Engineering, Tongji University, Shanghai, China.
Zhaoxia JiCenter for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Robert DamoiseuxCenter for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Yuqiang WangCollege of Pharmacy, Jinan University, Guangzhou, Guangdong, 510640, China.
André E NelCenter for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Shuo LinDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Funding

Predictive Toxicological Paradigm for Chronic Nanoparticle Injury in the LungR01ES016746 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NEL, ANDRE ELIAS · 2008 to 2017
$3.4M
NIEHS NIH HHS R01 ES016746
6 · The paper itself

Abstract

Recent studies suggest that the nanorods consisting of europium hydroxide could promote angiogenesis. In this study, it is sought to determine if additional types of nanoparticles are capable of enhancing angiogenesis and in addition, understand the underlying mechanisms. For this reason, a method is employed that combines a high throughput in vitro cell based screen coupled with an in vivo validation using vascular specific green fluorescent protein reporter transgenic zebrafish for examining proangiogenesis activity. After screening multiple types of nanoparticles, it is discovered that four of them, Eu(III) (OH)3 rods (Eu rods), Eu(III) (OH)3 spheres (Eu spheres), Tb(III) (OH)3 rods (Tb rods), and Tb(III) (OH)3 spheres (Tb spheres), are the most effective in promoting angiogenesis. It is also showed that ionic forms of europium nitrate [Eu(NO3 )3 ] (Eu) and terbium nitrate [Tb(NO3 )3 ] (Tb), the two lanthanide elements for these four nanoparticles, are also capable of enhancing angiogenesis. However, this effect is further enhanced by nanoparticle synthesis. Finally, it is demonstrated that reactive oxygen species H2 O2 is a key factor in the process of proangiogenesis by lanthanide elemental nanoparticles.

Indexed as

AnimalsLanthanoid Series ElementsNanoparticlesNeovascularization, PhysiologicReactive Oxygen SpeciesZebrafishLanthanoid Series ElementsReactive Oxygen Speciesangiogenesislanthanide nanoparticlesreactive oxygen specieszebrafish

Identifiers

PMID27383397
PMCPMC5240819

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.