ArticleScientific reports2016
Adaptive immunity against gut microbiota enhances apoE-mediated immune regulation and reduces atherosclerosis and western-diet-related inflammation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Bacterial extracellular vesicles in the initiation, progression and treatment of atherosclerosis.Gut microbes · 2025Review
- Multiomic Integration Reveals Taxonomic Shifts Correlate to Serum Cytokines in an Antibiotics Model of Gut Microbiome Disruption.Cellular and molecular bioengineering · 2025Article
- Systemic lupus erythematosus and atherosclerosis: immune pathways and the uncharted territory of gut microbiota and metabolism.Frontiers in immunology · 2025Review
- Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis.Frontiers in cardiovascular medicine · 2025Review
- Apolipoprotein E genotype affects innate susceptibility toInfection and immunity · 2023Article
- Review
- APOE genetics influence murine gut microbiome.Scientific reports · 2022Article
- The Types and Proportions of Commensal Microbiota Have a Predictive Value in Coronary Heart Disease.Journal of clinical medicine · 2021Review
- Reshaping of the gastrointestinal microbiome alters atherosclerotic plaque inflammation resolution in mice.Scientific reports · 2021Article
- Mutual Interplay of Host Immune System and Gut Microbiota in the Immunopathology of Atherosclerosis.International journal of molecular sciences · 2020Review
- Murine Gut Microbiome Association WithFrontiers in immunology · 2020Article
- The Genetic Variability ofGenes · 2019Review
- Could Alzheimer's Disease Originate in the Periphery and If So How So?Molecular neurobiology · 2019Review
- The role of diet in the prevention and treatment of Inflammatory Bowel Diseases.Acta bio-medica : Atenei Parmensis · 2018Review
- Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcScientific reports · 2017Article
- Diet, Gut Microbiome and Epigenetics: Emerging Links with Inflammatory Bowel Diseases and Prospects for Management and Prevention.Nutrients · 2017Review
- Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes.The Journal of nutrition · 2017Review
- Atheroregressive Potential of the Treatment with a Chimeric Monoclonal Antibody against Sulfated Glycosaminoglycans on Pre-existing Lesions in Apolipoprotein E-Deficient Mice.Frontiers in pharmacology · 2017Article
- Integrating diet and inflammation to calculate cardiovascular risk.Atherosclerosis · 2016Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common features of immune-metabolic and inflammatory diseases such as metabolic syndrome, diabetes, obesity and cardiovascular diseases are an altered gut microbiota composition and a systemic pro-inflammatory state. We demonstrate that active immunization against the outer membrane protein of bacteria present in the gut enhances local and systemic immune control via apoE-mediated immune-modulation. Reduction of western-diet-associated inflammation was obtained for more than eighteen weeks after immunization. Immunized mice had reduced serum cytokine levels, reduced insulin and fasting glucose concentrations; and gene expression in both liver and visceral adipose tissue confirmed a reduced inflammatory steady-state after immunization. Moreover, both gut and atherosclerotic plaques of immunized mice showed reduced inflammatory cells and an increased M2 macrophage fraction. These results suggest that adaptive responses directed against microbes present in our microbiota have systemic beneficial consequences and demonstrate the key role of apoE in this mechanism that could be exploited to treat immune-metabolic diseases.
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