ArticleScientific reports2016
Stiffness of the microenvironment upregulates ERBB2 expression in 3D cultures of MCF10A within the range of mammographic density.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
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- Embedded Living HER2+ Cells in a 3D Gelatin-Alginate Hydrogel as an In Vitro Model for Immunotherapy Delivery for Breast Cancer.Polymers · 2023Article
- Evaluating the Impact of a Biomimetic Mechanical Environment on Cancer Invasion and Matrix Remodeling.Advanced healthcare materials · 2023Article
- Deficiency of IntegrinFrontiers in cell and developmental biology · 2022Article
- Protein Ligands in the Secretome of CD36Cancers · 2021Article
- Three-dimensional decellularized tumor extracellular matrices with different stiffness as bioengineered tumor scaffolds.Bioactive materials · 2021Article
- Mammary epithelial morphogenesis in 3D combinatorial microenvironments.Scientific reports · 2020Article
- Cancer cells grown in 3D under fluid flow exhibit an aggressive phenotype and reduced responsiveness to the anti-cancer treatment doxorubicin.Scientific reports · 2020Article
- Overexpression of CD36 in mammary fibroblasts suppresses colony growth in breast cancer cell lines.Biochemical and biophysical research communications · 2020Article
- Organoid model of mammographic density displays a higher frequency of aberrant colony formations with radiation exposure.Bioinformatics (Oxford, England) · 2020Article
- YY1 is a cis-regulator in the organoid models of high mammographic density.Bioinformatics (Oxford, England) · 2020Article
- Feature-Based Representation Improves Color Decomposition and Nuclear Detection Using a Convolutional Neural Network.IEEE transactions on bio-medical engineering · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The effects of the stiffness of the microenvironment on the molecular response of 3D colony organization, at the maximum level of mammographic density (MD), are investigated. Phenotypic profiling reveals that 3D colony formation is heterogeneous and increased stiffness of the microenvironment, within the range of the MD, correlates with the increased frequency of aberrant 3D colony formation. Further integrative analysis of the genome-wide transcriptome and phenotypic profiling hypothesizes overexpression of ERBB2 in the premalignant MCF10A cell lines at a stiffness value that corresponds to the collagen component at high mammographic density. Subsequently, ERBB2 overexpression has been validated in the same cell line. Similar experiments with a more genetically stable cell line of 184A1 also revealed an increased frequency of aberrant colony formation with the increased stiffness; however, 184A1 did not demonstrate overexpression of ERBB2 at the same stiffness value of the high MD. These results suggest that stiffness exacerbates premalignant cell line of MCF10A.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.