ArticleeLife2016
A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers.
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Who cites it
180 citing papers in PubMed.
- High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.Human psychopharmacology · 2022Trial
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- The deficit of oligodendrocyte family cells in layer 3 of the dorsal anterior cingulate cortex in schizophrenia: possible interactions with dysfunction and altered microanatomy.European archives of psychiatry and clinical neuroscience · 2026Article
- Mechanisms of transcranial magnetic brain stimulation.Physiological reviews · 2026Review
- Myelin dysfunction in autism spectrum disorder: insights into core symptoms and mechanisms of brain development.Molecular psychiatry · 2026Review
- Zebrafish oligodendrocyte lineage cells use the postsynaptic protein Gephyrin to myelinate GABAergic axons and limit myelin sheath growth.Nature communications · 2026Article
- Cortical and white matter myelination proceed in concert during early infancy.Nature communications · 2026Article
- CA1 parvalbumin interneurons display alterations of myelin patterning driven by microgliosis in temporal lobe epilepsy.Scientific reports · 2026Article
- Article
- Cognitive Stimulation and Activity-Dependent Myelination: Oligodendroglial Mechanisms Linking Neural Activity and Brain Plasticity.International journal of molecular sciences · 2026Review
- Deficit of oligodendrocyte family cells in layer 5 of the dorsal anterior cingulate cortex in schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Myelin sheaths persist for weeks following axon degeneration.Science advances · 2026Article
- In vivo mapping of cortical amyloid beta-myelin coupling in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Differential Myeloarchitecture of Subfields of the Mammalian Auditory Cortex: A Comparative Approach.Brain, behavior and evolution · 2026Review
- Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication.Nature communications · 2025Article
- MaskGraphene: an advanced framework for interpretable joint representation for multi-slice, multi-condition spatial transcriptomics.Genome biology · 2025Article
- Demyelination-induced glutamatergic imbalance mediates hippocampal Hyperexcitability.Neurobiology of disease · 2025Article
- Simulation of evoked responses to transcranial magnetic stimulation using a multiscale cortical circuit model.bioRxiv : the preprint server for biology · 2025Article
- Layer-specific changes in sensory cortex across the lifespan in mice and humans.Nature neuroscience · 2025Article
- Transient juvenile demyelination impairs maturation and function of parvalbumin-positive interneurons in the prefrontal cortex.PLoS biology · 2025Article
120 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
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Abstract
Myelin is best known for its role in increasing the conduction velocity and metabolic efficiency of long-range excitatory axons. Accordingly, the myelin observed in neocortical gray matter is thought to mostly ensheath excitatory axons connecting to subcortical regions and distant cortical areas. Using independent analyses of light and electron microscopy data from mouse neocortex, we show that a surprisingly large fraction of cortical myelin (half the myelin in layer 2/3 and a quarter in layer 4) ensheathes axons of inhibitory neurons, specifically of parvalbumin-positive basket cells. This myelin differs significantly from that of excitatory axons in distribution and protein composition. Myelin on inhibitory axons is unlikely to meaningfully hasten the arrival of spikes at their pre-synaptic terminals, due to the patchy distribution and short path-lengths observed. Our results thus highlight the need for exploring alternative roles for myelin in neocortical circuits.
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