Evidence map›Paper›PMID 27383032›Full record

ArticleAdvanced healthcare materials2016

Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design.

Haitao Cui, Wei Zhu, Margaret Nowicki, Xuan Zhou, Ali Khademhosseini, Lijie Grace Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
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  5. 3D Hybrid Bioprinting for Complex Multi-Tissue Engineering.bioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Article
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  9. Skin substitutes: from conventional to 3D bioprinting.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Review
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  11. Review
  12. Article
  13. Article
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haitao CuiDepartment of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall 800 22nd Street NW, Washington, DC, 20052, USA.
Wei ZhuDepartment of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall 800 22nd Street NW, Washington, DC, 20052, USA.
Margaret NowickiDepartment of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall 800 22nd Street NW, Washington, DC, 20052, USA.
Xuan ZhouDepartment of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall 800 22nd Street NW, Washington, DC, 20052, USA.
Ali KhademhosseiniHarvard-MIT Division of Health Sciences and Technology, Wyss Institute for Biologically Inspired Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.
Lijie Grace ZhangDepartment of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall 800 22nd Street NW, Washington, DC, 20052, USA. lgzhang@gwu.edu.

Funding

A Novel 3D Bioprinted Smart Vascularized Nano TissueDP2EB020549 · NIBIB · GEORGE WASHINGTON UNIVERSITY · PI ZHANG, LIJIE GRACE · 2014 to 2014
$2.3M
NIBIB NIH HHS DP2 EB020549
6 · The paper itself

Abstract

A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel-inspired chemistry and "thiol-ene" click reaction are used to regionally immobilize bioactive factors during construct fabrication for modulating or improving cellular events.

Indexed as

Bone and BonesPrinting, Three-DimensionalTissue EngineeringHumansHuman Umbilical Vein Endothelial Cellsclick reactiondual 3D bioprintingmussel-inspired chemistryregional immobilizationvascularized complex tissue

Identifiers

PMID27383032
PMCPMC5014673

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.