Evidence map›Paper›PMID 27382604›Full record

Observational studyTheScientificWorldJournal2016

Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study.

Orlando Nascimento Terra Junior, Gabriel de Carvalho Maldonado, Guilherme Rohem Alfradique, Vinicius da Cunha Lisboa, Adriano Arnóbio, Dirce Bonfim de Lima, Hilda Rachel Diamond, Maria Helena Faria Ornellas de Souza

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in TheScientificWorldJournal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Orlando Nascimento Terra JuniorSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
Gabriel de Carvalho MaldonadoSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
Guilherme Rohem AlfradiqueSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
Vinicius da Cunha LisboaSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
Adriano ArnóbioSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
Dirce Bonfim de LimaSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
Hilda Rachel DiamondSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
Maria Helena Faria Ornellas de SouzaSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
Universidade do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The NCR receptors play a fundamental role in the cytotoxicity mediated by NK cells against tumor cells. In the current study, we investigated possible HIV/AIDS-related changes in the expression of the NCR receptors comparing healthy donors, HIV/AIDS patients, and HIV/AIDS patients with cancer (HIV/AIDSWC). The NCRs were quantified in NK cells (NK(dim) and NK(bright)) and T lymphocytes from peripheral blood samples by flow cytometry. We found a significant decrease in the frequency of NK cells expressing NKp46 in HIV/AIDS group (p = 0.0012). There was a decrease in the frequency of NK cells expressing NKp46 in the HIV/AIDSWC group; however, this was not statistically significant. We found a significant decrease in the frequency of NK cells expressing NKp30 in the HIV/AIDS group (p = 0.0144). There was a decrease in the frequency of NK cells expressing NKp30 and in the HIV/AIDSWC group, but this was not statistically significant. There were no changes in the distribution of NK cells and their subtypes in both groups.

Indexed as

Acquired Immunodeficiency SyndromeAdultAgedCase-Control StudiesCross-Sectional StudiesFemaleHIV InfectionsHumansKiller Cells, NaturalMaleMiddle AgedNatural Cytotoxicity Triggering Receptor 1Natural Cytotoxicity Triggering Receptor 3NeoplasmsYoung AdultNatural Cytotoxicity Triggering Receptor 1Natural Cytotoxicity Triggering Receptor 3NCR1 protein, humanNCR3 protein, human

Identifiers

PMID27382604
PMCPMC4921643
OpenAlexW2435559546

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.