ReviewEye and vision (London, England)2016
Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important?
Review in Eye and vision (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Early Detection of Keratoconus: Diagnostic Advances and Their Impact on Visual Outcomes: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Corneal biomechanical properties after SMILE versus FLEX, LASIK, LASEK, or PRK: a systematic review and meta-analysis.BMC ophthalmology · 2019Pooled it
- Effects of caffeine intake on the biomechanical properties of the cornea: a placebo-controlled, double-blind, crossover pilot study in low caffeine consumers.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Trial
- Effects of complete suture removal on corneal topography, ocular biometry, and IOL power after keratoplasty: a comparative study of PK and DALK.BMC ophthalmology · 2026Article
- Advancing subclinical keratoconus detection using polarization-sensitive optical coherence tomography and artificial intelligence.Biophotonics discovery · 2026Article
- Analysis of astigmatism type influence onFrontiers in bioengineering and biotechnology · 2026Article
- Proteomic Analysis Provides Insights Into PPIP5K2 Function and Its Impact on Corneal Energy Metabolism.Investigative ophthalmology & visual science · 2025Article
- The Impact of Small Incision Lenticule Extraction on the Biomechanical Properties of the Cornea: A Review.Bioengineering (Basel, Switzerland) · 2025Review
- Analysis of pulsatile motion in the murine cornea using phase-sensitive visible-light optical coherence tomography.Biomedical optics express · 2025Article
- Evaluating corneal cross-linking using Stress-Strain Index maps: a finite element study.Journal of the Royal Society, Interface · 2025Article
- Ultrafast line-field holographic elastography with single excitation for corneal biomechanical characterization.Biomedical optics express · 2025Article
- The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults.Translational vision science & technology · 2025Article
- The Application of Terahertz Technology in Corneas and Corneal Diseases: A Systematic Review.Bioengineering (Basel, Switzerland) · 2025Review
- Age-related analysis of corneal biomechanical parameters in healthy Chinese individuals.Scientific reports · 2024Article
- Keratoconus and Corneal Ectasia with Relatively Low Keratometry.Ophthalmology and therapy · 2024Article
- Multi-modal imaging for the detection of early keratoconus: a narrative review.Eye and vision (London, England) · 2024Review
- Corneal biomechanics in normal and subclinical keratoconus eyes.BMC ophthalmology · 2023Article
- Assessment of the corneal biomechanical features of granular corneal dystrophy type 2 using dynamic ultra-high-speed Scheimpflug imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Patient-specific air puff-induced loading using machine learning.Frontiers in bioengineering and biotechnology · 2023Article
- Biomechanics of keratoconus: Two numerical studies.PloS one · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Keratoconus is a bilateral, non-inflammatory, degenerative corneal disease. The occurrence and development of keratoconus is associated with corneal thinning and conical protrusion, which causes irregular astigmatism. With the disruption of the collagen organization, the cornea loses its shape and function resulting in progressive visual degradation. Currently, corneal topography is the most important tool for the diagnosis of keratoconus, which may lead to false negatives among the patient population in the subclinical phase. However, it is now hypothesised that biomechanical destabilisation of the cornea may take place ahead of the topographic evidence of keratoconus, hence possibly assisting with disease diagnosis and management. This article provides a review of the definition, diagnosis, and management strategies for keratoconus based on corneal biomechanics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.