ArticleBlood research2016
Prognostic relevance of the Ki-67 proliferation index in patients with mantle cell lymphoma.
Article in Blood research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Role of artificial intelligence in haematolymphoid diagnostics.Histopathology · 2025Review
- Fungating nasal mass as a rare presenting manifestation of relapsed mantle cell lymphoma.BMJ case reports · 2023Article
- Mantle Cell Lymphoma Presenting as Acute Abdominal Syndrome: A Rare Case Report and Literature Review.Healthcare (Basel, Switzerland) · 2021Article
- B Cell Lymphomas of the GI Tract.Current gastroenterology reports · 2021Review
- Article
- Ki67 and CD31 Differential Expression in Cutaneous T-Cell Lymphoma and Its Mimickers: Association with Clinicopathological Criteria and Disease Advancement.Clinical, cosmetic and investigational dermatology · 2020Article
- Proapoptotic protein BIM as a novel prognostic marker in mantle cell lymphoma.Human pathology · 2019Article
- Correlation Between Uptake ofTechnology in cancer research & treatment · 2019Article
- Mantle cell lymphoma presenting as bilateral adrenal huge masses.BMJ case reports · 2018Article
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6 authors.
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Abstract
backgroundA high Ki-67 proliferation index (PI) in neoplastic cells is associated with poor survival in mantle cell lymphoma (MCL). We aimed to determine the cut-off values for the Ki-67 PI as a prognostic factor in MCL according to bone marrow findings.
methodsImmunohistochemical (IHC) staining for Ki-67 was performed on formalin-fixed paraffin-embedded biopsy tissues from 56 patients with MCL. Patients were grouped based on their Ki-67 PI values. Survival analyses were carried out and the cut-off value for the Ki-67 PI was determined.
resultsOf the 56 patients, 39 (69.6%) showed bone marrow involvement of MCL; 21 of these patients had leukemic manifestations at the time of diagnosis. The results of the Ki-67 IHC staining were as follows: ≤10% in 22 patients, 11-20% in 14 patients, 21-30% in 3 patients, 31-40% in 4 patients, 41-50% in 4 patients, and >50% in 9 patients. A cut-off value of 20% revealed significantly different survival rates with mean survival times of 69.8 months (Ki-67 PI≤20%) and 47.9 months (Ki-67 PI>20%), irrespective of bone marrow findings (P=0.034). Clinical outcomes did not differ, regardless of bone marrow findings. However, in cases with bone marrow involvement, the Ki-67 cut-off value of 30% for overall survival was required to yield statistical significance (P=0.033).
conclusionThe 20% cut-off value for the Ki-67 PI was clinically meaningful, regardless of bone marrow involvement of MCL. For patients with bone marrow involvement, the statistically significant cut-off value increased to 30%.
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