ArticleBlood research2016
Platelet count recovery after intravenous immunoglobulin predicts a favorable outcome in children with immune thrombocytopenia.
Article in Blood research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Prediction of the Clinical Course of Immune Thrombocytopenia in Children by Platelet Kinetics.HemaSphere · 2023Article
- Biological stratification of clinical disease courses in childhood immune thrombocytopenia.Journal of thrombosis and haemostasis : JTH · 2021Article
- Severe immune thrombocytopenic purpura after SARS-CoV-2 vaccine.Archive of clinical cases · 2021Article
- Transient and chronic childhood immune thrombocytopenia are distinctly affected by Fc-γ receptor polymorphisms.Blood advances · 2019Article
- Platelet-specific antibodies and differences in their expression in childhood immune thrombocytopenic purpura predicts clinical progression.Pediatric investigation · 2018Article
- Management of immune thrombocytopenia: Korean experts recommendation in 2017.Blood research · 2017Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildhood immune thrombocytopenic purpura (ITP) is a common acquired bleeding disorder. Even though most children recover, either spontaneously or with therapy, 10-20% of newly diagnosed ITP cases have a chronic course beyond 12 months. This study evaluated whether clinical and laboratory findings can predict the response to intravenous immunoglobulin (IVIG) and progression to persistent or chronic ITP in children.
methodsDuring the period between March 2003 and June 2015, we retrospectively analyzed 72 children, newly diagnosed with ITP, who received IVIG treatment. Peripheral blood counts were obtained at diagnosis and at 1, 3, 6, and 12 months after IVIG treatment.
resultsAfter 6 months of IVIG treatment, 14 of 72 patients (19.4%) had persistent ITP, and after 12 months, 7 of 40 patients (17.5%) had chronic ITP. Age at diagnosis, gender, history of viral infection, or vaccination before disease onset were not statistically correlated with platelet recovery at 6 and 12 months. However, a platelet count recovery of ≥100×10(3)/µL at 1 and 3 months was significantly correlated with platelet recovery at 6 (P<0.001 and P<0.001, respectively) and 12 (P=0.007 and P=0.004, respectively) months.
conclusionThis study demonstrated that early platelet count recovery, at 1 and 3 months after IVIG treatment, predicts a short disease duration and a favorable outcome in children with newly diagnosed ITP. Further investigation in a larger group of patients is warranted to validate these findings.
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