ArticleJournal of International Society of Preventive & Community Dentistry
Evaluation of the effect of hydrogen peroxide as a mouthwash in comparison with chlorhexidine in chronic periodontitis patients: A clinical study.
Article in Journal of International Society of Preventive & Community Dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03412071 (Testing the Ability of a Microbiome - Focused Intervention to Reduce HIV Susceptibility in Ugandan Men), which is not on this map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Testing the Ability of a Microbiome - Focused Intervention to Reduce HIV Susceptibility in Ugandan Men
Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Comparative effects of hydrogen peroxide (Nanosil) and chlorhexidine mouthwashes on healing and pain after impacted mandibular third molar surgery: a randomized clinical trial.BMC oral health · 2025Trial
- Efficacy of preprocedural mouth rinses (Chlorhexidine, essential oil, and hydrogen peroxide) in reducing bacterial aerosols during dental scaling.BMC oral health · 2025Trial
- Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial.Cell reports. Medicine · 2024Trial
- N-acetyl cysteine versus chlorhexidine mouthwashes in prevention and treatment of experimental gingivitis: a randomized, triple-blind, placebo-controlled clinical trial.Clinical oral investigations · 2019Trial
- The Effect of Oral Care Product Ingredients on Oral Pathogenic Bacteria Transcriptomics Through RNA-Seq.Microorganisms · 2024Article
- Anti-Periodontopathogenic Ability of Mangrove Leaves (Aegiceras corniculatum) Ethanol Extract: In silico and in vitro study.European journal of dentistry · 2023Article
- Non-surgical Periodontal Treatment: SRP and Innovative Therapeutic Approaches.Advances in experimental medicine and biology · 2022Article
- Rhamnolipids and surfactin inhibit the growth or formation of oral bacterial biofilm.BMC microbiology · 2020Article
- A Systematic Review of the Effect of Oral Rinsing with HInternational journal of dentistry · 2020Review
- Article
- Over-the-counter mouthwash use and risk of pre-diabetes/diabetes.Nitric oxide : biology and chemistry · 2017Article
- Guidelines for dental implants in the times of COVID-19.National journal of maxillofacial surgeryReview
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS AND
objectiveThis study was conducted to evaluate the effect of hydrogen peroxide (H2O2) as a mouthwash in comparison with chlorhexidine (CHX) in chronic periodontitis patients. MATERIALS AND
methodsA total of 45 patients suffering from localized mild to moderate chronic periodontitis were chosen. The subjects were divided equally into three groups. Group A patients were treated only with scaling and root planning (SRP). Group B were treated with SRP in combination with 0.2% CHX gluconate mouthwash twice daily for 10 days. Group C were treated with SRP in combination with 1.5% H2O2 mouthwash twice daily for 10 days. Gingival index, plaque index, pocket depth, and clinical attachment level were recorded for patients of all groups on day 0 (Baseline), 15, 30, and 90, respectively. Statistical analysis was done using the Statistical Package for the Social Sciences version 22.0. Repeated measures analysis of variance was used to assess the differences in the abovementioned indices because of time and groups.
resultsBoth CHX gluconate and H2O2 mouthwashes significantly reduced the gingival index more than that observed in the control group, but similar to each other. There were no significant differences in the clinical attachment loss, plaque index, and pocket depth among the study groups, but improvement was seen within the CHX group participants. In participants with chronic periodontitis, SRP in combination with 0.2% CHX gluconate mouthwash was an effective treatment in reducing the gingival index and the pocket depth, as well as improving the clinical attachment level.
conclusionThe use of CHX gluconate was observed to be higher than H2O2 for the reduction in the gingival index and the pocket depth, as well as for the improvement of the clinical attachment level.
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