ArticleGenes & cancer2016
Decreased expression of let-7c is associated with non-response of muscle-invasive bladder cancer patients to neoadjuvant chemotherapy.
Article in Genes & cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Effects of Let-7c on the processing of hepatitis B virus associated liver diseases.Infectious agents and cancer · 2022Article
- MicroRNA signature for estimating the survival time in patients with bladder urothelial carcinoma.Scientific reports · 2022Article
- Can increased expression of miR-Let-7c reduce the transition potential of high-grade urothelial carcinoma?Molecular biology reports · 2021Article
- [miR-let-7c-5p inhibits invasion and migration of bladder cancer cells by targeting HMGA2].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Urinary expression of let-7c cluster as non-invasive tool to assess the risk of disease progression in patients with high grade non-muscle invasive bladder Cancer: a pilot study.Journal of experimental & clinical cancer research : CR · 2020Article
- miR-143 expression profiles in urinary bladder cancer: correlation with clinical and epidemiological parameters.Molecular biology reports · 2020Article
- Evaluating prognostic utility of preoperative Neutrophil to Lymphocyte Ratio and hsa-let-7g/c up-regulation in patients with urinary bladder cancer.Cancer biomarkers : section A of Disease markers · 2020Article
- MicroRNAs: Key Players in Bladder Cancer.Molecular diagnosis & therapy · 2019Review
- Genipin inhibits the growth of human bladder cancer cells via inactivation of PI3K/Akt signaling.Oncology letters · 2018Article
- MicroRNA profiling of dogs with transitional cell carcinoma of the bladder using blood and urine samples.BMC veterinary research · 2017Article
- Dysregulation of miRNAs in bladder cancer: altered expression with aberrant biogenesis procedure.Oncotarget · 2017Review
- Review
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Authors and funding
8 authors.
Funding
Abstract
The identification and development of biomarkers which predict response of muscle invasive bladder cancer (MIBC) patients to neoadjuvant chemotherapy would likely increase usage of this treatment option and thereby improve patient survival rates. MiRNA array and qRT-PCR validation was used to identify miRNA which are associated with response to neoadjuvant chemotherapy. RNA was extracted from a total of 41 archival, fully annotated, MIBC patient diagnostic biopsies (20 chemo-responders and 21 non-responders (response is defined as > 5 year survival rate and being pT0 post-chemotherapy)). Microarray and qPCR identified let-7c as being differentially expressed in chemo-responder versus non-responder patients. Patients with higher let-7c expression levels had significantly higher odds of responding to chemotherapy (p = 0.023, OR 2.493, 95% CI 1.121, 5.546), and assessment of let-7c levels allowed for prediction of patient response (AUC 0.72, positive predictive value 59%). Decreased let-7c was associated with MIBC incidence (p < 0.001), and significantly correlated with other related miRNA including those that were not differentially expressed between responders and non-responders. The combined data indicate let-7c plays a role in mediating chemoresistance to neoadjuvant chemotherapy in MIBC patients, and is a modest, yet clinically meaningful, predictor of patient response.
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