ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2016
Effects of systemic administration of ibuprofen on stress response in a rat model of post-traumatic stress disorder.
Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- The Multivariate Effect of Ketamine on PTSD: Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2022Pooled it
- Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR.Nature communications · 2020Pooled it
- Investigation of the effects of two exercise protocols on behavioral and biochemical changes in ovariectomized rats exposed to single prolonged stress.IBRO neuroscience reports · 2026Article
- Oral administration of MCT oil reduces anxiety-like behavior and is associated with differences in serum BDNF responses in a rat model of PTSD.Scientific reports · 2026Article
- Machine learning and bioinformatics framework integration reveal potential characteristic genes related to immune cell infiltration in post-traumatic stress disorder.Scientific reports · 2025Article
- PET Imaging Unveils Neuroinflammatory Mechanisms in Psychiatric Disorders: From Microglial Activation to Therapeutic Innovation.Molecular neurobiology · 2025Review
- Thiamine Compounds Alleviate Oxidative Stress, Over-Expression of Pro-Inflammatory Markers and Behavioral Abnormalities in a Mouse Predation Model of PTSD.International journal of molecular sciences · 2025Article
- Post traumatic stress disorder associated hypothalamic-pituitary-adrenal axis dysregulation and physical illness.Brain, behavior, & immunity - health · 2024Review
- Involvement of dysregulated hippocampal histone H3K9 methylation at the promoter of the BDNF gene in impaired memory extinction.Psychopharmacology · 2024Article
- A rare olive compound oleacein functions as a TrkB agonist and mitigates neuroinflammation both in vitro and in vivo.Cell communication and signaling : CCS · 2024Article
- Innate and adaptive immune system consequences of post-traumatic stress disorder.Autonomic neuroscience : basic & clinical · 2024Review
- Sex-dependent effects of angiotensin II type 1 receptor blocker on molecular and behavioral changes induced by single prolonged stress.Behavioural brain research · 2023Article
- A prolonged stress rat model recapitulates some PTSD-like changes in sleep and neuronal connectivity.Communications biology · 2023Article
- Sex-specific immune mechanisms in PTSD symptomatology and risk: A translational overview and perspectives.Brain research bulletin · 2023Review
- Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder.Journal of natural medicines · 2022Article
- The role of the immune system in posttraumatic stress disorder.Translational psychiatry · 2022Review
- Predator Scent-Induced Sensitization of Hypertension and Anxiety-like Behaviors.Cellular and molecular neurobiology · 2022Article
- Neuroinflammation in Post-Traumatic Stress Disorder.Biomedicines · 2022Review
- Sex-dependent effects of microglial reduction on impaired fear extinction induced by single prolonged stress.Frontiers in behavioral neuroscience · 2022Article
- Myricetin Inhibited Fear and Anxiety-Like Behaviors by HPA Axis Regulation and Activation of the BDNF-ERK Signaling Pathway in Posttraumatic Stress Disorder Rats.Evidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pro-inflammatory cytokine and brain-derived neurotrophic factor (BDNF) are modulated in post-traumatic stress disorder (PTSD). This study investigated the effects of ibuprofen (IBU) on enhanced anxiety in a rat model of PTSD induced by a single prolonged stress (SPS) procedure. The effects of IBU on inflammation and BDNF modulation in the hippocampus and the mechanisms underlying for anxiolytic action of IBU were also investigated. Male Sprague-Dawley rats were given IBU (20 or 40 mg/kg, i.p., once daily) for 14 days. Daily IBU (40 mg/kg) administration signifi cantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index in the EPM test, and increased the time spent in the center of an open fi eld after SPS. IBU administration signifi cantly decreased the expression of pro-inflammatory mediators, such as tumor necrosis factor-α, interleukin-1β, and BDNF, in the hippocampus, as assessed by reverse transcription-polymerase chain reaction analysis and immunohistochemistry. These fi ndings suggest that IBU exerts a therapeutic effect on PTSD that might be at least partially mediated by alleviation of anxiety symptoms due to its anti-inflammatory activity and BDNF expression in the rat brain.
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