ArticleNeuropsychiatric disease and treatment2016
Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention.
Article in Neuropsychiatric disease and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- The Impact of a Randomized Sleep Education Intervention for College Students.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Trial
- The Relationship Between Sleep Quality and Prodromal Symptoms in Euthymic Patients with Bipolar Disorder.Noro psikiyatri arsivi · 2026Article
- The prevalence and risk factors of sleep disturbances among mental health patients following hospital discharge.Frontiers in public health · 2025Article
- Associations between post-traumatic stress symptoms and quality of life among psychiatric healthcare personnel in China during the COVID-19 pandemic: A network approach.Frontiers in psychiatry · 2023Article
- Machiavellianism and psychopathy affect sleep quality in people with affective disorders and mentally healthy individuals.Frontiers in psychology · 2023Article
- Sleep quality of adult psychiatric outpatients at Chris Hani Baragwanath Academic Hospital.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2023Article
- The anxiety levels, quality of sleep and life and problem-solving skills in healthcare workers employed in COVID-19 services.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2020Article
- Article
- The Relationship between Sleep Habits and Mental Health in Iranian Elementary School Children.Sleep science (Sao Paulo, Brazil)Article
- The Brazilian-Portuguese version of the Sleep Hygiene Index (SHI): validity, reliability and association with depressive symptoms and sleep-related outcomes.Sleep science (Sao Paulo, Brazil)Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSleep disturbances are a common co-occurring disturbance in patients with major depressive disorders (MDDs) and accordingly deserve particular attention. Using a randomized design, we investigated the effects of three different adjuvant interventions on sleep and depression among patients with MDD: a sleep hygiene program (SHP), lorazepam (LOR), and their combination (SHP-LOR).
methodsA total of 120 outpatients with diagnosed MDD (mean age: 48.25 years; 56.7% females) and treated with a standard SSRI (citalopram at 20-40 mg at therapeutic level) were randomly assigned to one of the following three conditions: SHP (n=40), LOR (1 mg/d; n=40), SHP-LOR (1 mg/d; n=40). At the beginning and at the end of the study 8 weeks later, patients completed two questionnaires, the Pittsburgh Sleep Quality Index to assess sleep and the Beck Depression Inventory to assess symptoms of depression.
resultsSleep disturbances decreased over time and in all groups. No group differences or interactions were observed. Symptoms of depression decreased over time and in all three groups. Reduction in symptoms of depression was greatest in the SHP-LOR group and lowest in the LOR group.
conclusionThe pattern of results suggests that all three adjuvant treatments improved symptoms of sleep disturbances and depression, with greater benefits for the SHP-LOR for symptoms of depression, but not for sleep. Nevertheless, risks and benefits of benzodiazepine prescriptions should be taken into account.
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