ArticleJournal of human reproductive sciences
Morphokinetic behavior of euploid and aneuploid embryos analyzed by time-lapse in embryoscope.
Article in Journal of human reproductive sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Trial
- Impact of semen quality on the risk of direct cleavage in human embryos.Journal of assisted reproduction and genetics · 2026Observational
- Prediction of human embryo ploidy based on morphokinetic parameters: Investigating the use of time-lapse imaging for non-invasive embryo selection.JBRA assisted reproduction · 2025Article
- Machine learning in time-lapse imaging to differentiate embryos from young vs old mice†.Biology of reproduction · 2024Article
- A non-invasive artificial intelligence approach for the prediction of human blastocyst ploidy: a retrospective model development and validation study.The Lancet. Digital health · 2023Article
- Time-Lapse Embryo culture: A better understanding of embryo development and clinical application.JBRA assisted reproduction · 2022Review
- An artificial intelligence model (euploid prediction algorithm) can predict embryo ploidy status based on time-lapse data.Reproductive biology and endocrinology : RB&E · 2021Article
- Assessing the impact of delayed blastulation using time lapse morphokinetics and preimplantation genetic testing in an IVF patient population.Journal of assisted reproduction and genetics · 2019Article
- Does polycystic ovary syndrome affect morphokinetics or abnormalities in early embryonic development?European journal of obstetrics & gynecology and reproductive biology: X · 2019Article
- Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations.Journal of assisted reproduction and genetics · 2019Article
- Are computational applications the "crystal ball" in the IVF laboratory? The evolution from mathematics to artificial intelligence.Journal of assisted reproduction and genetics · 2018Review
- The clinical use of time-lapse in human-assisted reproduction.Therapeutic advances in reproductive healthReview
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6 authors.
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Abstract
backgroundEmbryonic aneuploidy may result in miscarriage, implantation failure, or birth defects. Thus, it is clinically necessary to avoid the selection of aneuploid embryos during in vitro fertilization treatment.
aimThe aim of this study was to identify the morphokinetic differences by analyzing the development of euploid and aneuploid embryos using a time-lapse technology. We also checked the accuracy of a previously described model for selection of euploid embryos based on morphokinetics in our study population. MATERIALS AND
methodsIt is a retrospective study of 29 cycles undergoing preimplantation genetic screening from October 2013 to April 2015 at our center. Of 253 embryos, 167 suitable for biopsy embryos were analyzed for their chromosomal status using array-comparative genome hybridization (CGH). The morphokinetic behavior of these embryos was further analyzed in embryoscope using time-lapse technology.
resultsAmong the analyzed embryos, 41 had normal and 126 had abnormal chromosome content. No significant difference in morphokinetics was found between euploid and aneuploid embryos. The percentage of embryos with blastulation was similar in the euploid (65.85%, 27/41) and aneuploid (60.31%, 76/126) embryos (P = 0.76). Although hard to define, majority of the chromosomal defects might be due to meiotic errors. On applying embryo selection model from Basile et al., embryos falling within optimal ranges for time to division to 5 cells (t5), time period of the third cell cycle (CC3), and time from 2 cell division to 5 cell division (t5-t2) exhibited greater proportion of normal embryos than those falling outside the optimal ranges (28.6%, 25.9%, and 26.7% vs. 17.5%, 20.8%, and 14.3%).
conclusionKeeping a track of time interval between two stages can help us recognize aneuploid embryos at an earlier stage and prevent their selection of transfer. However, it cannot be used as a substitute for array CGH to select euploid embryos for transfer.
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