Evidence map›Paper›PMID 27382056›Full record

ArticleThe Journal of biological chemistry2016

A Mouse Model for Dietary Xenosialitis: ANTIBODIES TO XENOGLYCAN CAN REDUCE FERTILITY.

Fang Ma, Liwen Deng, Patrick Secrest, Linda Shi, June Zhao, Pascal Gagneux

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

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  12. Proceedings of the National Academy of Sciences of the United States of America · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Fang MaFrom the Sichuan University - The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, and Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China and.
Liwen Dengthe Glycobiology Research and Training Center and Department of Pathology.
Patrick Secrestthe Glycobiology Research and Training Center and Department of Pathology.
Linda ShiDepartment of Bioengineering, and.
June ZhaoTransgenic Mouse Core, University of California - San Diego, La Jolla, California 92093.
Pascal Gagneuxthe Glycobiology Research and Training Center and Department of Pathology, pgagneux@ucsd.edu.
Bioengineering Center · RUUniversity of California, San Diego · USWest China Second University Hospital of Sichuan University · CN

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Glycan Diversity and Anti-Glycan Antibodies as Barriers to Gene FlowR01GM095882 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAGNEUX, PASCAL · 2011 to 2015
$1.4M
NIGMS NIH HHS R01 GM095882NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Humans can incorporate the xenoglycan N-glycolylneuraminic acid (Neu5Gc) from the diet into reproductive tissues and secretions. Most humans also have circulating antibodies specific for this dietary xenoglycan. The potential for inflammation induced by incorporated Neu5Gc and circulating anti-Neu5Gc antibodies, termed xenosialitis, has been discussed as a factor influencing several human diseases. Potential effects of xenosialitis on human fertility remain unknown. Here, we investigate possible adverse effects of the presence of Neu5Gc on sperm or endometrium combined with anti-Neu5Gc antibodies in semen or uterine secretions in a mouse model. We use Cmah(-/-) mice, humanized for Neu5Gc deficiency. We find that the viability, migration, and capacitation of sperm with incorporated Neu5Gc are negatively affected when these are exposed to anti-Neu5Gc antibodies. In addition, we find that after copulation, activated uterine neutrophils and macrophages show increased phagocytosis of sperm in the presence of anti-Neu5Gc antibodies via the complement receptor 3 (C3R) and Fcγ I/II/III (Fc receptor). Furthermore, Neu5Gc in endometrial cells combined with the presence of anti-Neu5Gc antibodies alters the receptivity and decidualization of endometrial explants. These studies provide mechanistic insights on how Neu5Gc on sperm and/or endometrium combined with anti-Neu5Gc antibodies in semen and uterine fluid might contribute to unexplained human infertility.

Indexed as

SialadenitisAnimalsDisease Models, AnimalEndometriumFemaleHumansMaleMiceMice, KnockoutMixed Function OxygenasesNeuraminic AcidsReceptors, ComplementReceptors, FcSpermatozoaCMPacetylneuraminate monooxygenaseMixed Function OxygenasesNeuraminic AcidsN-glycolylneuraminic acidReceptors, ComplementReceptors, Fcanimal modelanti-carbohydrate antibodiesautoimmunitydietinfertilityN-Glycolylneuraminic acidsialic acidspermatozoaxenoglycan

Identifiers

PMID27382056
PMCPMC5000070
OpenAlexW2462637967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.