Evidence map›Paper›PMID 27382022›Full record

ArticleInfection and immunity2016

Beneficial Effects of Sodium Phenylbutyrate Administration during Infection with Salmonella enterica Serovar Typhimurium.

Stefan Jellbauer, Araceli Perez Lopez, Judith Behnsen, Nina Gao, Thao Nguyen, Clodagh Murphy, Robert A Edwards, Manuela Raffatellu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  9. Eradication ofJournal of fungi (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Stefan JellbauerDepartment of Microbiology, University of California Irvine, Irvine, California, USA Institute for Immunology, University of California Irvine, Irvine, California, USA.
Araceli Perez LopezDepartment of Microbiology, University of California Irvine, Irvine, California, USA Institute for Immunology, University of California Irvine, Irvine, California, USA.
Judith BehnsenDepartment of Microbiology, University of California Irvine, Irvine, California, USA Institute for Immunology, University of California Irvine, Irvine, California, USA.
Nina GaoDepartment of Microbiology, University of California Irvine, Irvine, California, USA Institute for Immunology, University of California Irvine, Irvine, California, USA.
Thao NguyenDepartment of Microbiology, University of California Irvine, Irvine, California, USA Institute for Immunology, University of California Irvine, Irvine, California, USA.
Clodagh MurphyDepartment of Microbiology, University of California Irvine, Irvine, California, USA Institute for Immunology, University of California Irvine, Irvine, California, USA.
Robert A EdwardsInstitute for Immunology, University of California Irvine, Irvine, California, USA Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, California, USA.
Manuela RaffatelluDepartment of Microbiology, University of California Irvine, Irvine, California, USA Institute for Immunology, University of California Irvine, Irvine, California, USA manuelar@uci.edu.
University of California, Irvine · US

Funding

INTESTINAL VITAMIN H UPTAKE--MOLECULAR/CELL REGULATIONR01DK058057 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2000 to 2019
$6.8M
Mucosal barrier function during Salmonella infectionR01AI083663 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI RAFFATELLU, MANUELA · 2010 to 2014
$1.9M
Development of siderophore-based vaccines against non-typhoidal Salmonella infectionR01AI114625 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2015 to 2019
$1.9M
The new chemokine CCL28 and its role during Salmonella infectionR21AI121928 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAFFATELLU, MANUELA, ZLOTNIK, ALBERT · 2016 to 2017
$425k
The role of the circadian clock during Salmonella infectionR21AI105374 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI RAFFATELLU, MANUELA, SASSONE-CORSI, PAOLO · 2014 to 2015
$424k
Targeting iron acquisition in Salmonella with siderophore-based immunizationR21AI101784 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2014 to 2015
$418k
Harnessing iron acquisition to hinder enterobacterial pathogenesisR56AI114625 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2022 to 2022
$400k
NIAID NIH HHS R01 AI083663NIAID NIH HHS R01 AI114625NIAID NIH HHS R21 AI101784NIAID NIH HHS R21 AI105374NIAID NIH HHS R21 AI121928NIAID NIH HHS R56 AI114625NIDDK NIH HHS R01 DK058057
6 · The paper itself

Abstract

Sodium phenylbutyrate (PBA) is a derivative of the short-chain fatty acid butyrate and is approved for treatment of urea cycle disorders and progressive familial intrahepatic cholestasis type 2. Previously known functions include histone deacetylase inhibitor, endoplasmic reticulum stress inhibitor, ammonia sink, and chemical chaperone. Here, we show that PBA has a previously undiscovered protective role in host mucosal defense during infection. Administration of PBA to Taconic mice resulted in the increase of intestinal Lactobacillales and segmented filamentous bacteria (SFB), as well as an increase of interleukin 17 (IL-17) production by intestinal cells. This effect was not observed in Jackson Laboratory mice, which are not colonized with SFB. Because previous studies showed that IL-17 plays a protective role during infection with mucosal pathogens, we hypothesized that Taconic mice treated with PBA would be more resistant to infection with Salmonella enterica serovar Typhimurium (S Typhimurium). By using the streptomycin-treated mouse model, we found that Taconic mice treated with PBA exhibited significantly lower S Typhimurium intestinal colonization and dissemination to the reticuloendothelial system, as well as lower levels of inflammation. The lower levels of S Typhimurium gut colonization and intestinal inflammation were not observed in Jackson Laboratory mice. Although PBA had no direct effect on bacterial replication, its administration reduced S Typhimurium epithelial cell invasion and lowered the induction of the proinflammatory cytokine IL-23 in macrophage-like cells. These effects likely contributed to the better outcome of infection in PBA-treated mice. Overall, our results suggest that PBA induces changes in the microbiota and in the mucosal immune response that can be beneficial to the host during infection with S Typhimurium and possibly other enteric pathogens.

Indexed as

AnimalsDisease Models, AnimalImmunity, MucosalInflammationInterleukin-17Interleukin-23IntestinesLactobacillalesMiceMice, Inbred C57BLPhenylbutyratesSalmonella Infections, AnimalSalmonella typhimuriumStreptomycin4-phenylbutyric acidInterleukin-17Interleukin-23PhenylbutyratesStreptomycin

Identifiers

PMID27382022
PMCPMC4995890
OpenAlexW2467565811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.