ArticleScientific reports2016
Neural substrates predicting short-term improvement of tinnitus loudness and distress after modified tinnitus retraining therapy.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Tailor-made notched music training-induced residual inhibition in subjective tinnitus: resting-state EEG spectral power ratio evidence.Frontiers in neuroscience · 2026Trial
- Sex-specific alterations of cerebral blood flow in subjective tinnitus patients: an arterial spin labeling study.Frontiers in neuroscience · 2026Article
- A scoping review of tinnitus research undertaken by New Zealand researchers: Aotearoa-an international hotspot for tinnitus innovation and collaboration.Journal of the Royal Society of New Zealand · 2025Review
- EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training.Frontiers in neuroscience · 2023Article
- Recovering Hidden Responder Groups in Individuals Receiving Neurofeedback for Tinnitus.Frontiers in neuroscience · 2022Article
- Triple network activation causes tinnitus in patients with sudden sensorineural hearing loss: A model-based volume-entropy analysis.Frontiers in neuroscience · 2022Article
- The balance between Bayesian inference and default mode determines the generation of tinnitus from decreased auditory input: A volume entropy-based study.Human brain mapping · 2021Article
- Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus.Human brain mapping · 2021Article
- Altered functional connectivity of the thalamus in tinnitus patients is correlated with symptom alleviation after sound therapy.Brain imaging and behavior · 2020Article
- Neurocognition of Aged Patients With Chronic Tinnitus: Focus on Mild Cognitive Impairment.Clinical and experimental otorhinolaryngology · 2020Article
- Single-Session of Combined tDCS-TMS May Increase Therapeutic Effects in Subjects With Tinnitus.Frontiers in neurology · 2020Article
- Pre-treatment Ongoing Cortical Oscillatory Activity Predicts Improvement of Tinnitus After Partial Peripheral Reafferentation With Hearing Aids.Frontiers in neuroscience · 2020Article
- The effects of sound therapy in tinnitus are characterized by altered limbic and auditory networks.Brain communications · 2020Article
- Cortical Oscillatory Signatures Reveal the Prerequisites for Tinnitus Perception: A Comparison of Subjects With Sudden Sensorineural Hearing Loss With and Without Tinnitus.Frontiers in neuroscience · 2020Article
- Corticostriatal functional connectivity of bothersome tinnitus in single-sided deafness.Scientific reports · 2019Article
- Changes in the Resting-State Cortical Oscillatory Activity 6 Months After Modified Tinnitus Retraining Therapy.Frontiers in neuroscience · 2019Article
- Chronic tinnitus and the limbic system: Reappraising brain structural effects of distress and affective symptoms.NeuroImage. Clinical · 2019Article
- Baseline Functional Connectivity Features of Neural Network Nodes Can Predict Improvement After Sound Therapy Through Adjusted Narrow Band Noise in Tinnitus Patients.Frontiers in neuroscience · 2019Article
- Article
- Typewriter tinnitus revisited: The typical symptoms and the initial response to carbamazepine are the most reliable diagnostic clues.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although tinnitus retraining therapy (TRT) is efficacious in most patients, the exact mechanism is unclear and no predictor of improvement is available. We correlated the extent of improvement with pre-TRT quantitative electroencephalography (qEEG) findings to identify neural predictors of improvement after TRT. Thirty-two patients with debilitating tinnitus were prospectively enrolled, and qEEG data were recorded before their initial TRT sessions. Three months later, these qEEG findings were correlated with the percentage improvements in the Tinnitus Handicap Inventory (THI) scores, and numeric rating scale (NRS) scores of tinnitus loudness and tinnitus perception. The THI score improvement was positively correlated with the pre-treatment activities of the left insula and the left rostral and pregenual anterior cingulate cortices (rACC/pgACC), which control parasympathetic activity. Additionally, the activities of the right auditory cortices and the parahippocampus, areas that generate tinnitus, negatively correlated with improvements in loudness. Improvements in the NRS scores of tinnitus perception correlated positively with the pre-TRT activities of the bilateral rACC/pgACC, areas suggested to form the core of the noise-canceling system. The current study supports both the classical neurophysiological and integrative models of tinnitus; our results serve as a milestone in the development of precision medicine in the context of TRT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.