Evidence map›Paper›PMID 27381968›Full record

Trial reportDiabetes & metabolic syndrome

Effect of weight loss on renal function in overweight and obese patients with heart failure.

Marjan Motie, Lorraine S Evangelista, Dawn Lombardo, Josiah Hoi, Tamara B Horwich, Michele Hamilton, Gregg C Fonarow

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes & metabolic syndrome. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marjan MotieProgram in Nursing Science, University of California Irvine, Irvine, CA, United States. Electronic address: mmotie@uci.edu.
Lorraine S EvangelistaProgram in Nursing Science, University of California Irvine, Irvine, CA, United States.
Dawn LombardoClinical Heart Failure Program, Department of Medicine, University of California Irvine Medical Center, Irvine, CA, United States.
Josiah HoiProgram in Nursing Science, University of California Irvine, Irvine, CA, United States.
Tamara B HorwichCardiology University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, CA, United States.
Michele HamiltonMedicine/Cardiology UCLA, Heart Failure Program, Cedars-Sinai Heart Institute, Los Angeles, CA, United States.
Gregg C FonarowAhmanson-UCLA Cardiomyopathy Center, Cardiology David Geffen School of Medicine, Los Angeles, CA, United States.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
Examining the Effects of High Protein Diet on Outcomes in Heart Failure PatientsR01HL093466 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EVANGELISTA, LORRAINE S · 2009 to 2013
$1.9M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR001414NHLBI NIH HHS R01 HL093466
6 · The paper itself

Abstract

aimsThe effect of intentional weight loss on glomerular filtration rate (GFR) in overweight and obese patients with heart failure (HF), diabetes mellitus (DM) and/or metabolic syndrome (MS) has not been studied. The purpose of the present study is to assess the short term effects of intentional weight loss on renal function in this population. MATERIALS AND

methodsFifty nine patients were recruited to participate in a 3-month intensive behavioral weight management intervention and received one of two standard structured energy-restricted meal plans (1200 or 1500kcal/day) based on their computed calorie deficit. Weight and renal function (serum creatinine, BUN and estimated glomerular filtration rate based on two formulas - Modification in Renal Disease Study (MDRD), and modified version of Cockcroft-Gault formula reported by Salazar Corcoran for obese patients (absolute and relative formulas) - were evaluated at baseline and at 3 months.

resultsParticipants had eGFR in the normal range at baseline and lost an average of 7.56±14.9 pounds (p<0.0001) over 3 months; however, there was no significant reduction in serum creatinine, BUN or eGFR.

conclusionThis study provides evidence that intentional weight loss in overweight and obese patients with HF along with DM, and/or MS and normal baseline renal function does not adversely affect renal function overtime.

Indexed as

Weight LossWeight Reduction ProgramsAdultAgedAged, 80 and overBody CompositionDiabetes ComplicationsFemaleGlomerular Filtration RateHeart FailureHumansKidneyMaleMetabolic SyndromeMiddle AgedObesityHeart failureHyperfiltrationObesityRenal functionWeight loss

Identifiers

PMID27381968
PMCPMC5182197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.