ArticleScientific reports2016
Spherulization as a process for the exudation of chemical cues by the encrusting sponge C. crambe.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Complete ectosome formation from the choanosome during whole-body regeneration of the sponge Hymeniacidon heliophila (Wilson 1911) using an in vitro microexplant model.In vitro cellular & developmental biology. Animal · 2026Article
- Nudibranch Cadlina rumia discriminates waterborne cues to find prey and conspecifics and avoid threats.BMC zoology · 2026Article
- Marine Mycobiomes Colonize Mediterranean Sponge Hosts in a Random Fashion.Microbial ecology · 2025Article
- Chemical Investigation of the Mediterranean SpongeMarine drugs · 2024Article
- Article
- Diving into the Molecular Diversity ofACS omega · 2022Article
- Barrettides: A Peptide Family Specifically Produced by the Deep-Sea SpongeJournal of natural products · 2021Article
- From waste of marine culture to natural patch in cardiac tissue engineering.Bioactive materials · 2021Article
- Opisthobranch grazing results in mobilisation of spherulous cells and re-allocation of secondary metabolites in the sponge Aplysina aerophoba.Scientific reports · 2020Article
- New Ecological Role of Seaweed Secondary Metabolites as Autotoxic and Allelopathic.Frontiers in plant science · 2020Article
- Marine Metabolomics: a Method for Nontargeted Measurement of Metabolites in Seawater by Gas Chromatography-Mass Spectrometry.mSystems · 2019Article
- Review
- Long-term experimentalPeerJ · 2018Article
- How Environmental Factors Affect the Production of Guanidine Alkaloids by the Mediterranean Sponge Crambe crambe.Marine drugs · 2017Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Ecological interactions in the marine environment are now recognized to be partly held by chemical cues produced by marine organisms. In particular, sponges are sessile animals thought to rely on the bioactive substances they synthesize to ensure their development and defense. However, the mechanisms leading the sponges to use their specialized metabolites as chemical cues remain unknown. Here we report the constant release of bioactive polycyclic guanidinic alkaloids by the Mediterranean sponge Crambe crambe into the dissolved and the particulate phases using a targeted metabolomics study. These compounds were proven to be stored into already described specialized (spherulous) sponge cells and dispersed into the water column after release through the sponge exhaling channels (oscula), leading to a chemical shield surrounding the sponge. Low concentrations of these compounds were demonstrated to have teratogenic effects on embryos of a common sea squirt (ascidian). This mechanism of action called spherulization may therefore contribute to the ecological success of encrusting sponges that need to extend their substrate cover to expand.
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