Evidence map›Paper›PMID 27381822›Full record

ArticleScientific reports2016

Altered resting-state neural activity and changes following a craving behavioral intervention for Internet gaming disorder.

Jin-Tao Zhang, Yuan-Wei Yao, Marc N Potenza, Cui-Cui Xia, Jing Lan, Lu Liu, Ling-Jiao Wang, Ben Liu, Shan-Shan Ma, Xiao-Yi Fang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
29.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Treatments for Internet gaming disorder and Internet addiction: A systematic review.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2017
    Pooled it
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Gaming disorder: Neural mechanisms and ongoing debates.Journal of behavioral addictions · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jin-Tao ZhangState Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Yuan-Wei YaoState Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Marc N PotenzaDepartments of Psychiatry and Neuroscience, Child Study Center, and CASAColumbia, Yale University School of Medicine, New Haven, CT 06519, USA.
Cui-Cui XiaStudents Counseling Center, Beijing Normal University, Beijing 100875, China.
Jing LanInstitute of Developmental Psychology, Beijing Normal University, Beijing 100875, China.
Lu LiuInstitute of Developmental Psychology, Beijing Normal University, Beijing 100875, China.
Ling-Jiao WangState Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Ben LiuState Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Shan-Shan MaState Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Xiao-Yi FangInstitute of Developmental Psychology, Beijing Normal University, Beijing 100875, China.
Beijing Normal University · CNChinese Institute for Brain Research · CNYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
TSF to enhance treatment of cocaine dependenceP50DA009241 · NIDA · YALE UNIVERSITY · PI CARROLL, KATHLEEN M. · 1994 to 2018
$40.5M
Neural mechanisms of CBT in cocaine dependence (Gender Differences Supplement)R01DA035058 · NIDA · YALE UNIVERSITY · PI CARROLL, KATHLEEN M., POTENZA, MARC N · 2013 to 2016
$2.3M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS P50 DA009241NIDA NIH HHS R01 DA035058
6 · The paper itself

Abstract

Internet gaming disorder (IGD) has become a serious mental health issue worldwide. Evaluating the benefits of interventions for IGD is of great significance. Thirty-six young adults with IGD and 19 healthy comparison (HC) subjects were recruited and underwent resting-state fMRI scanning. Twenty IGD subjects participated in a group craving behavioral intervention (CBI) and were scanned before and after the intervention. The remaining 16 IGD subjects did not receive an intervention. The results showed that IGD subjects showed decreased amplitude of low fluctuation in the orbital frontal cortex and posterior cingulate cortex, and exhibited increased resting-state functional connectivity between the posterior cingulate cortex and dorsolateral prefrontal cortex, compared with HC subjects. Compared with IGD subjects who did not receive the intervention, those receiving CBI demonstrated significantly reduced resting-state functional connectivity between the: (1) orbital frontal cortex with hippocampus/parahippocampal gyrus; and, (2) posterior cingulate cortex with supplementary motor area, precentral gyrus, and postcentral gyrus. These findings suggest that IGD is associated with abnormal resting-state neural activity in reward-related, default mode and executive control networks. Thus, the CBI may exert effects by reducing interactions between regions within a reward-related network, and across the default mode and executive control networks.

Indexed as

Behavior, AddictiveBrain MappingCase-Control StudiesCravingFemaleFrontal LobeGyrus CinguliHumansInternetMagnetic Resonance ImagingMaleVideo GamesYoung Adult

Identifiers

PMID27381822
PMCPMC4933876
OpenAlexW2473671351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.