ArticleThe Journal of clinical investigation1989
Local abnormalities of coagulation and fibrinolytic pathways that promote alveolar fibrin deposition in the lungs of baboons with diffuse alveolar damage.
Article in The Journal of clinical investigation, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 80 citations in OpenAlex.
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- The Contribution of the Urokinase Plasminogen Activator and the Urokinase Receptor to Pleural and Parenchymal Lung Injury and Repair: A Narrative Review.International journal of molecular sciences · 2021Review
- Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Vascular permeability in the fibrotic lung.The European respiratory journal · 2020Article
- Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.Physiological reviews · 2020Review
- Nebulization of Single-Chain Tissue-Type and Single-Chain Urokinase Plasminogen Activator for Treatment of Inhalational Smoke-Induced Acute Lung Injury.Journal of drug delivery science and technology · 2018Article
- Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator.Clinical and translational medicine · 2018Article
- Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: A Prospective Pilot Study.Frontiers in medicine · 2016Article
- Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation.Toxicology and applied pharmacology · 2013Article
- Platelets induce endothelial tissue factor expression in a mouse model of acid-induced lung injury.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Airway tissue factor-dependent coagulation activity in response to sulfur mustard analog 2-chloroethyl ethyl sulfide.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor.Thorax · 2007Article
- Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation.American journal of respiratory cell and molecular biology · 2007Article
- The role of metallothionein in the pathogenesis of acute lung injury.American journal of respiratory cell and molecular biology · 2006Article
- Gene expression changes during the development of acute lung injury: role of transforming growth factor beta.American journal of respiratory and critical care medicine · 2005Article
- The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system.The American journal of pathology · 2000Article
- Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.The Journal of clinical investigation · 1996Article
- Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse.The Journal of clinical investigation · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Because alveolar fibrin is a prominent histologic feature of diffuse lung injury in baboons, we hypothesized that local abnormalities of pathways of fibrin turnover would favor fibrin deposition in the alveolar space. To test this hypothesis, procoagulant and fibrinolytic activities were characterized in serial bronchoalveolar lavage (BAL) of baboons with evolving diffuse alveolar damage (DAD) induced by exposure to 100% O2. BAL procoagulant activity, characterized mainly as the tissue factor-Factor VII complex, was markedly increased after induction of DAD. Extrinsic pathway inhibitor was likewise increased in BAL during evolving DAD but was insufficient to control coagulation. Urokinase-like fibrinolytic activity was usually detectable in baseline BAL but was undetectable after 7 d of O2. DAD BAL contained significantly increased plasminogen levels, plasmin inhibitor activity sufficient to neutralize all plasmin produced by BAL plasminogen activator found in control BAL and detectable plasminogen activator inhibitor-1. Antiplasmin activity was due, in part, to increased alpha 2-antiplasmin. These changes correlated with quantitatively increased alveolar fibrin deposition demonstrated by histologic and morphometric analyses. Multiple abnormalities of pathways of fibrin turnover occur concurrently in the alveolar compartment of the lungs of baboons with DAD, which collectively predispose to diffuse alveolar fibrin deposition.
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