ReviewProgress in biophysics and molecular biology2016
The biological default state of cell proliferation with variation and motility, a fundamental principle for a theory of organisms.
Review in Progress in biophysics and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- The "Selfish Cell": The Central Role of Metabolism in Relaying Environmental Stimuli and Controlling Cellular Function.Biology · 2026Review
- The end of the genetic paradigm of cancer.PLoS biology · 2025Review
- Empirical vitalism: observing an organism's formative power within an active and co-constitutive relation between subject and object.History and philosophy of the life sciences · 2025Article
- Mathematical Modeling in the Study of Organisms and Their Parts.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Naturalizing relevance realization: why agency and cognition are fundamentally not computational.Frontiers in psychology · 2024Article
- Modeling Mammary Organogenesis from Biological First Principles: A Systems Biology Approach.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Challenges and Opportunities Modeling the Dynamic Tumor Matrisome.BME frontiers · 2023Review
- Recent advances in aggregation-induced emission luminogens in photoacoustic imaging.European journal of nuclear medicine and molecular imaging · 2022Review
- A computational model of organism development and carcinogenesis resulting from cells' bioelectric properties and communication.Scientific reports · 2022Article
- On biological individuation.Theory in biosciences = Theorie in den Biowissenschaften · 2022Article
- Biological constraints as norms in evolution.History and philosophy of the life sciences · 2022Article
- The cancer puzzle: Welcome to organicism.Progress in biophysics and molecular biology · 2021Article
- From Wingspread to CLARITY: a personal trajectory.Nature reviews. Endocrinology · 2021Review
- Cancer associated fibroblast: Mediators of tumorigenesis.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- Over a century of cancer research: Inconvenient truths and promising leads.PLoS biology · 2020Article
- Information, programme, signal: dead metaphors that negate the agency of organisms.Interdisciplinary science reviews : ISR · 2020Article
- Sleeping Beauty and the Microenvironment Enchantment: Microenvironmental Regulation of the Proliferation-Quiescence Decision in Normal Tissues and in Cancer Development.Frontiers in cell and developmental biology · 2018Review
- An Integrative Approach Toward Biology, Organisms, and Cancer.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Why do we need theories?Progress in biophysics and molecular biology · 2016Review
- Modeling mammary organogenesis from biological first principles: Cells and their physical constraints.Progress in biophysics and molecular biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The principle of inertia is central to the modern scientific revolution. By postulating this principle Galileo at once identified a pertinent physical observable (momentum) and a conservation law (momentum conservation). He then could scientifically analyze what modifies inertial movement: gravitation and friction. Inertia, the default state in mechanics, represented a major theoretical commitment: there is no need to explain uniform rectilinear motion, rather, there is a need to explain departures from it. By analogy, we propose a biological default state of proliferation with variation and motility. From this theoretical commitment, what requires explanation is proliferative quiescence, lack of variation, lack of movement. That proliferation is the default state is axiomatic for biologists studying unicellular organisms. Moreover, it is implied in Darwin's "descent with modification". Although a "default state" is a theoretical construct and a limit case that does not need to be instantiated, conditions that closely resemble unrestrained cell proliferation are readily obtained experimentally. We will illustrate theoretical and experimental consequences of applying and of ignoring this principle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.