ArticleScientific reports2016
Evolutionary pressures on microbial metabolic strategies in the chemostat.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Adaptive Laboratory Evolution inMicroorganisms · 2026Review
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- Oropharyngeal, proximal colonic, and vaginal microbiomes of healthy Korean native black pig gilts.BMC microbiology · 2023Article
- Towards evolutionary predictions: Current promises and challenges.Evolutionary applications · 2023Review
- Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies.Nature communications · 2022Article
- Online estimation of changing metabolic capacities in continuous Corynebacterium glutamicum cultivations growing on a complex sugar mixture.Biotechnology and bioengineering · 2022Article
- The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes.Molecules (Basel, Switzerland) · 2021Review
- Induction of amylase and protease as antibiofilm agents by starch, casein, and yeast extract in Arthrobacter sp. CW01.BMC microbiology · 2021Article
- Selection for rapid uptake of scarce or fluctuating resource explains vulnerability of glycolysis to imbalance.PLoS computational biology · 2021Article
- Fungal evolution: cellular, genomic and metabolic complexity.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Rapid Colonization of Uranium Mining-Impacted Waters, the Biodiversity of Successful Lineages of Phytoplankton Extremophiles.Microbial ecology · 2020Article
- Transcriptome-guided parsimonious flux analysis improves predictions with metabolic networks in complex environments.PLoS computational biology · 2020Article
- Continual evolution through coupled fast and slow feedbacks.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Trusting the hand that feeds: microbes evolve to anticipate a serial transfer protocol as individuals or collectives.BMC evolutionary biology · 2019Article
- Segregostat: a novel concept to control phenotypic diversification dynamics on the example of Gram-negative bacteria.Microbial biotechnology · 2019Article
- Cell population heterogeneity driven by stochastic partition and growth optimality.Scientific reports · 2019Article
- Noise propagation in an integrated model of bacterial gene expression and growth.PLoS computational biology · 2018Article
- Metabolic enzyme cost explains variable trade-offs between microbial growth rate and yield.PLoS computational biology · 2018Article
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4 authors.
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Abstract
Protein expression is shaped by evolutionary processes that tune microbial fitness. The limited biosynthetic capacity of a cell constrains protein expression and forces the cell to carefully manage its protein economy. In a chemostat, the physiology of the cell feeds back on the growth conditions, hindering intuitive understanding of how changes in protein concentration affect fitness. Here, we aim to provide a theoretical framework that addresses the selective pressures and optimal evolutionary-strategies in the chemostat. We show that the optimal enzyme levels are the result of a trade-off between the cost of their production and the benefit of their catalytic function. We also show that deviations from optimal enzyme levels are directly related to selection coefficients. The maximal fitness strategy for an organism in the chemostat is to express a well-defined metabolic subsystem known as an elementary flux mode. Using a coarse-grained, kinetic model of Saccharomyces cerevisiae's metabolism and growth, we illustrate that the dynamics and outcome of evolution in a chemostat can be very counter-intuitive: Strictly-respiring and strictly-fermenting strains can evolve from a common ancestor. This work provides a theoretical framework that relates a kinetic, mechanistic view on metabolism with cellular physiology and evolutionary dynamics in the chemostat.
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