Evidence map›Paper›PMID 27381425›Full record

ArticleExperimental neurology2016

Neuromodulation of the neural circuits controlling the lower urinary tract.

Parag N Gad, Roland R Roy, Hui Zhong, Yury P Gerasimenko, Giuliano Taccola, V Reggie Edgerton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 44 citations in OpenAlex.

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  19. Cell biology of spinal cord injury and repair.The Journal of clinical investigation · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Parag N GadDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA.
Roland R RoyDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, CA 90095, USA.
Hui ZhongDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA.
Yury P GerasimenkoDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA; Pavlov Institute of Physiology, St. Petersburg 199034, Russia.
Giuliano TaccolaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA; Neuroscience Department, International School for Advanced Studies (SISSA), Bonomea 265, Trieste, Italy.
V Reggie EdgertonDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA; Department of Neurobiology, University of California, Los Angeles, CA 90095, USA; Department of Neurosurgery, University of California, Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, CA 90095, USA. Electronic address: vre@ucla.edu.
University of California, Los Angeles · USPavlov Institute of Physiology of the Russian Academy of Sciences · RU

Funding

Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCIR01EB007615 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE · 2008 to 2013
$4.9M
Spinal Epidural Electrode Array To Facilitate Standing and Stepping After SCIU01EB007615 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE, GAD, PARAG · 2014 to 2018
$4.8M
NIBIB NIH HHS R01 EB007615NIBIB NIH HHS U01 EB007615
6 · The paper itself

Abstract

The inability to control timely bladder emptying is one of the most serious challenges among the many functional deficits that occur after a spinal cord injury. We previously demonstrated that electrodes placed epidurally on the dorsum of the spinal cord can be used in animals and humans to recover postural and locomotor function after complete paralysis and can be used to enable voiding in spinal rats. In the present study, we examined the neuromodulation of lower urinary tract function associated with acute epidural spinal cord stimulation, locomotion, and peripheral nerve stimulation in adult rats. Herein we demonstrate that electrically evoked potentials in the hindlimb muscles and external urethral sphincter are modulated uniquely when the rat is stepping bipedally and not voiding, immediately pre-voiding, or when voiding. We also show that spinal cord stimulation can effectively neuromodulate the lower urinary tract via frequency-dependent stimulation patterns and that neural peripheral nerve stimulation can activate the external urethral sphincter both directly and via relays in the spinal cord. The data demonstrate that the sensorimotor networks controlling bladder and locomotion are highly integrated neurophysiologically and behaviorally and demonstrate how these two functions are modulated by sensory input from the tibial and pudental nerves. A more detailed understanding of the high level of interaction between these networks could lead to the integration of multiple neurophysiological strategies to improve bladder function. These data suggest that the development of strategies to improve bladder function should simultaneously engage these highly integrated networks in an activity-dependent manner.

Indexed as

Electric Stimulation TherapyUrinationAnimalsDisease Models, AnimalElectrodes, ImplantedElectromyographyEvoked Potentials, MotorExercise TherapyFemaleHindlimbLocomotionMuscle, SkeletalNeural PathwaysPeripheral NervesRatsRats, Sprague-DawleyEpidural stimulationLocomotor trainingLower urinary tractTibial nerve stimulation

Identifiers

PMID27381425
PMCPMC5559194
OpenAlexW2464172222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.