Evidence map›Paper›PMID 27381341›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2018

Prediction of 14-year cardiovascular outcomes by dobutamine stress

Stefan Roest, Hendrik J Boiten, Ron T van Domburg, Roelf Valkema, Arend F L Schinkel

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Prediction of 14-year cardiovascular outcomes by dobutamine stress 99mTc-tetrofosmin myocardial perfusion SPECT; methodological issues in prediction studies.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  3. Prognostic accuracy of myocardial perfusion imaging in octogenarians.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  4. Stress myocardial perfusion imaging in the elderly.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Stefan RoestDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Thoraxcenter Room Ba304, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
Hendrik J BoitenDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Thoraxcenter Room Ba304, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. henkjan_boiten@hotmail.com.
Ron T van DomburgDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Thoraxcenter Room Ba304, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
Roelf ValkemaDepartment of Nuclear Medicine, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
Arend F L SchinkelDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Thoraxcenter Room Ba304, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDobutamine stress myocardial perfusion imaging (MPI) is a useful alternative for the evaluation of coronary artery disease (CAD) in elderly patients who are unable to perform an exercise stress test. However, data on the long-term prognostic value of stress MPI in elderly patients are lacking. Therefore, this study evaluated the long-term prognostic value of dobutamine stress MPI in elderly patients unable to perform an exercise test.

methodsThe study population consisted of 247 elderly patients (mean age 71 ± 5 years) who underwent dobutamine stress single-photon emission computed tomography (SPECT) MPI. An abnormal SPECT study was defined as the presence of fixed and/or reversible perfusion defects. A summed stress score (SSS) was obtained to estimate the extent and severity of perfusion defects. End points during follow-up were all-cause mortality, cardiac mortality, and nonfatal myocardial infarction (MI).

resultsDuring a median follow-up of 14 years (range 12-16), 168 (68%) patients died (all-cause mortality), of which 56 (23%) were due to cardiac causes. Nonfatal MI occurred in 19 (8%) patients. Kaplan-Meier survival curves showed that MPI provided optimal risk stratification in patients with normal and abnormal MPI. Multivariable analysis identified an abnormal MPI as a strong significant predictor of all-cause mortality and cardiac events. A multivariable analysis also revealed that a reversible defect and SSS were strong long-term predictors of cardiac mortality and hard cardiac events.

conclusionDobutamine stress

Indexed as

Myocardial Perfusion ImagingTomography, Emission-Computed, Single-PhotonAgedAged, 80 and overCoronary Artery DiseaseDisease ProgressionDobutamineExercise TestFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMyocardial InfarctionOrganophosphorus CompoundsOrganotechnetium CompoundsDobutamineOrganophosphorus CompoundsOrganotechnetium CompoundsRadiopharmaceuticalstechnetium tc-99m tetrofosmin99mTc-tetrofosmincoronary artery diseasedobutamine stress SPECTelderlylong-term prognosis

Identifiers

PMID27381341

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.