Evidence map›Paper›PMID 27381324›Full record

ArticleHeredity2016

Commercial chicken breeds exhibit highly divergent patterns of linkage disequilibrium.

R J Pengelly, A A Gheyas, R Kuo, E Mossotto, E G Seaby, D W Burt, S Ennis, A Collins

Open access · bronzeAbstract read
In one paragraph

Article in Heredity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

R J PengellyHuman Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.
A A GheyasThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
R KuoThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
E MossottoHuman Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.
E G SeabyHuman Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.
D W BurtThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
S EnnisHuman Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.
A CollinsHuman Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.
University of Southampton · GBRoslin Institute · GB

Funding

Biotechnology and Biological Sciences Research Council
6 · The paper itself

Abstract

The analysis of linkage disequilibrium (LD) underpins the development of effective genotyping technologies, trait mapping and understanding of biological mechanisms such as those driving recombination and the impact of selection. We apply the Malécot-Morton model of LD to create additive LD maps that describe the high-resolution LD landscape of commercial chickens. We investigated LD in chickens (Gallus gallus) at the highest resolution to date for broiler, white egg and brown egg layer commercial lines. There is minimal concordance between breeds of fine-scale LD patterns (correlation coefficient <0.21), and even between discrete broiler lines. Regions of LD breakdown, which may align with recombination hot spots, are enriched near CpG islands and transcription start sites (P<2.2 × 10

Indexed as

Linkage DisequilibriumRecombination, GeneticAnimalsBreedingChickensChromosome MappingGenetics, PopulationGenotyping TechniquesPolymorphism, Single NucleotideSequence Analysis, DNA

Identifiers

PMID27381324
PMCPMC5061916
OpenAlexW2461289679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.